A diffusion tensor imaging and neuropsychological study of prospective memory impairment in South African HIV positive individuals.

Metabolic Brain Disease
Jacqueline HoareJohn A Joska

Abstract

HIV-associated prospective memory (ProM) impairment has emerged, in earlier studies as a significant predictor of medication management and independence in activities of daily living. The relationship between ProM and white matter integrity in HIV has not previously been investigated. Participants, including 128 HIV-infected individuals and 32 healthy controls, were assessed using a comprehensive neuropsychological evaluation and both objective and subjective measures of ProM. Diffusion tensor imaging (DTI) was utilized to investigate the relationship of white matter integrity to ProM in a randomly selected subsample of 40 HIV positive subjects, using a whole brain voxel-based approach to define fractional anisotrophy (FA) and mean diffusion (MD). Total prospective memory was significantly poorer in the HIV positive group when compared with healthy controls (p = 0.023). Time-based ProM was poorer in the HIV group compared to healthy controls both without prompts (p = 0.001) and with prompts (p = 0.001). Poor Total ProM score correlated with performance on neuropsychological tests of executive functioning, information processing speed, learning, and working memory (p < 0.05). Those HIV positive participants with poor ProM had si...Continue Reading

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Citations

Dec 17, 2014·Tropical Medicine & International Health : TM & IH·Lena Morgon BanksHannah Kuper
Sep 25, 2014·Current Opinion in HIV and AIDS·Beau M Ances, Dima A Hammoud
Aug 4, 2016·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Virawudh SoontornniyomkijUNKNOWN Translational Methamphetamine AIDS Research Center (TMARC) Group
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Aug 25, 2021·Current HIV/AIDS Reports·Susmita SilShilpa Buch
Aug 30, 2019·Dementia and Geriatric Cognitive Disorders·Yen-Hsuan HsuMin-Chien Tu

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