A diffusion-weighted imaging informed continuum model of the rabbit triceps surae complex

Biomechanics and Modeling in Mechanobiology
M AlipourJ Fernandez

Abstract

The NZ white rabbit is the animal of choice for much experimental work due to its muscular frame and similar response to human diseases, and is one of the few mammals that have had their genome sequenced. However, continuum-level computational models of rabbit muscle detailing fibre architecture are limited in the literature, especially the triceps surae complex (gastrocnemius, plantaris and soleus), which has similar biomechanics and translatable findings to the human. This study presents a geometrical model of the rabbit triceps surae informed with diffusion-weighted imaging (DWI)-based fibres. Passive rabbit-specific material properties are estimated using known muscle deformation inferred from magnetic resonance imaging data and dorsiflexion force measured with a custom-built rabbit rig and transducer. Muscle shape prediction is evaluated against a second rabbit. This study revealed that the triceps surae steady-state force post-rigor is close to post-mortem for small deformations but increases by a fixed ratio as the deformation increases and can be used to evaluate the passive behaviour of muscle. DWI fibre orientation significantly influences shape and mechanics during simulated computational muscle contraction. The pres...Continue Reading

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Dec 21, 2018·Journal of Applied Physiology·R D HerbertS C Gandevia
Sep 22, 2018·Journal of Applied Physiology·Lynne E BilstonShantanu Sinha
Sep 29, 2020·Frontiers in Physiology·James M WakelingNilima Nigam

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