A DiI-tracing study of the neural connections of the pineal organ in two elasmobranchs (Scyliorhinus canicula and Raja montagui) suggests a pineal projection to the midbrain GnRH-immunoreactive nucleus

Cell and Tissue Research
M MandadoJ Yáñez

Abstract

The pineal organ of elasmobranchs is an elongated photoreceptive organ. In order to investigate the afferent and efferent connections of the pineal organ of two elasmobranchs, the skate (Raja montagui) and the dogfish (Scyliorhinus canicula), a fluorescent carbocyanine (DiI) was applied to the pineal organ of paraformaldehyde-fixed brains. This application strongly labeled the pineal tract, which formed extensive bilateral projections. In both species, the pinealofugal fibers coursed to the dorsomedial thalamus, the medial pretectal area, the posterior tubercle, and the medial mesencephalic tegmentum and branched profusely in these areas. Application of DiI to the pineal organ also labeled occasional perikarya in the dorsomedial thalamus, posterior commissural region, posterior tubercle, and mesencephalic tegmentum. A comparison of these results with those of immunocytochemical analyses of the dogfish brain with an anti-salmon gonadotropin-releasing hormone (sGnRH) antiserum revealed a close topographical relation between the pineal projections and the midbrain sGnRH-immunoreactive (ir) nucleus, the only structure in the dogfish brain that contained sGnRHir neurons. This and the widespread distribution of sGnRHir fibers in the ...Continue Reading

Citations

Mar 22, 2007·PLoS Biology·Thomas DickmeisNicholas S Foulkes
Oct 19, 2010·Hormones and Behavior·Paul M Forlano, Andrew H Bass
May 5, 2009·General and Comparative Endocrinology·J FalcónM Carrillo
Oct 18, 2008·The Journal of Comparative Neurology·Iván CarreraIsabel Rodríguez-Moldes
Mar 31, 2015·Nature Communications·Ronan LagadecAgnès Boutet
Aug 24, 2006·Brain, Behavior and Evolution·María del Carmen de Arriba, Manuel A Pombal
Jan 3, 2018·The Journal of Comparative Neurology·Julián YáñezRamón Anadón

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