A dinitro-functionalized metal-organic framework featuring visual and fluorogenic sensing of H2 S in living cells, human blood plasma and environmental samples

The Analyst
Soutick NandiShyam Biswas

Abstract

Here, we describe a new dinitro-functionalized Zr(iv) MOF (MOF = metal-organic framework) having a UiO-66 (UiO = University of Oslo) framework topology called UiO-66-(NO2)2 (1). It shows fluorescence turn-on behavior towards H2S in simulated biological medium (HEPES buffer, pH = 7.4). By employing solvothermal conditions, 1 was successfully synthesized by reacting ZrCl4, H2BDC-(NO2)2 [H2BDC-(NO2)2 = 2,5-dinitro-1,4-benzenedicarboxylic acid] ligand and benzoic acid with a molar ratio of 1 : 1 : 10 in DMF (DMF = N,N-dimethylformamide) at 130 °C for 24 h. The material was characterized by infrared spectroscopy, X-ray powder diffraction (XRPD) and thermogravimetric (TG) analyses. The compound not only displays highly sensitive fluorometric sensing of H2S but also exhibits a visually detectable colorimetric change towards H2S in daylight. Moreover, the high selectivity of 1' towards H2S is retained even when several other biologically intrusive species co-exist in the sensing medium. The limit of detection (LOD) of the compound is 14.14 μM which lies in the range of the H2S concentration found in biological systems. Fluorescence microscopy studies on J774A.1 cells revealed the efficacy of the probe for imaging H2S in living cells. M...Continue Reading

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Citations

Jun 5, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Soutick Nandi, Shyam Biswas
Aug 6, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Mostakim SkShyam Biswas
Nov 19, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Aniruddha DasShyam Biswas
Aug 29, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Soutick NandiShyam Biswas
Jul 1, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Rana DalapatiShyam Biswas
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·He ZhangGuibin Jiang
Jan 15, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Chiranjib GogoiShyam Biswas
Nov 27, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Soutick NandiShyam Biswas
Nov 15, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Aniruddha DasShyam Biswas
Jun 15, 2021·Chemical Science·Eva Martínez-AhumadaIlich A Ibarra
Aug 7, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Subhrajyoti Ghosh, Shyam Biswas

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Methods Mentioned

BETA
X-ray
fluorescence
fluorescence microscopy

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