A direct GABAergic output from the basal ganglia to frontal cortex

Nature
Arpiar SaundersBernardo L Sabatini

Abstract

The basal ganglia are phylogenetically conserved subcortical nuclei necessary for coordinated motor action and reward learning. Current models postulate that the basal ganglia modulate cerebral cortex indirectly via an inhibitory output to thalamus, bidirectionally controlled by direct- and indirect-pathway striatal projection neurons (dSPNs and iSPNs, respectively). The basal ganglia thalamic output sculpts cortical activity by interacting with signals from sensory and motor systems. Here we describe a direct projection from the globus pallidus externus (GP), a central nucleus of the basal ganglia, to frontal regions of the cerebral cortex (FC). Two cell types make up the GP-FC projection, distinguished by their electrophysiological properties, cortical projections and expression of choline acetyltransferase (ChAT), a synthetic enzyme for the neurotransmitter acetylcholine (ACh). Despite these differences, ChAT(+) cells, which have been historically identified as an extension of the nucleus basalis, as well as ChAT(-) cells, release the inhibitory neurotransmitter GABA (γ-aminobutyric acid) and are inhibited by iSPNs and dSPNs of dorsal striatum. Thus, GP-FC cells comprise a direct GABAergic/cholinergic projection under the co...Continue Reading

References

Oct 1, 1989·Trends in Neurosciences·R L AlbinJ B Penney
May 1, 1971·Journal of Neurophysiology·M R DeLong
Aug 6, 1998·Neuroscience·D R SmithM Gallagher
Jun 18, 2002·Neuroscience Research·Atsushi NambuMasahiko Takada
Jul 9, 2002·The European Journal of Neuroscience·Martin Sarter, John P Bruno
Jul 24, 2002·The International Journal of Neuropsychopharmacology·Brian Paul Blum, J John Mann
Jun 12, 2003·Trends in Neurosciences·Wolfram SchultzJeffrey R Hollerman
Apr 2, 2005·Nature Reviews. Neuroscience·David A LewisDavid W Volk
May 23, 2006·Nature Reviews. Neuroscience·Henry H Yin, Barbara J Knowlton
Aug 31, 2006·Physiological Genomics·Yvonne N TalliniMichael I Kotlikoff
May 15, 2007·Progress in Brain Research·Hitoshi Kita
Sep 15, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shiaoching GongCharles R Gerfen
Jun 23, 2009·Bipolar Disorders·Mauricio Tohen, Eduard Vieta
Nov 12, 2010·Nature·Thomas R Insel
Jun 1, 1986·IEEE Transactions on Pattern Analysis and Machine Intelligence·J Canny
Feb 4, 2012·Nature Protocols·Manuel MarxDirk Feldmeyer
Jun 26, 2012·Neuron·Nicolas MalletPeter J Magill
Aug 7, 2012·Frontiers in Neural Circuits·Arpiar SaundersBernardo L Sabatini
May 9, 2013·Frontiers in Cellular Neuroscience·Elizabeth ScarrBrian Dean
Nov 6, 2013·Trends in Neurosciences·Jesse H GoldbergMichale S Fee
Nov 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benjamin S FreezeAnatol C Kreitzer
Jul 25, 2014·Nature·UNKNOWN Schizophrenia Working Group of the Psychiatric Genomics Consortium

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Citations

Feb 13, 2016·Nature Reviews. Neuroscience·Nicolas X TritschBernardo L Sabatini
Dec 4, 2015·ELife·Jian-Zhong GuoAdam W Hantman
Feb 3, 2016·Brain Structure & Function·S MongiaE Mengual
Jul 30, 2015·Neuropharmacology·Adam J GrangerBernardo L Sabatini
Jan 23, 2016·Behavioral and Brain Functions : BBF·Hyopil KimBong-Kiun Kaang
Feb 24, 2016·Brain Structure & Function·María Guadalupe García-GomarLuis Concha
Jan 20, 2016·Molecular Psychiatry·N OkadaR Hashimoto
Mar 12, 2016·Cell·Talia N LernerKarl Deisseroth
Sep 29, 2015·Trends in Cognitive Sciences·Josef P RauscheckerMarkus Ploner
Mar 31, 2016·Brain Structure & Function·Lara Eid, Martin Parent
Oct 7, 2015·Frontiers in Neuroanatomy·Rosa M VillalbaYoland Smith
May 15, 2015·Synapse·Lara Eid, Martin Parent
Jul 28, 2015·Nature Neuroscience·Yonatan M KupchikPeter W Kalivas
Nov 4, 2015·Current Behavioral Neuroscience Reports·Mitra Heshmati, Scott J Russo
Jun 2, 2015·Frontiers in Systems Neuroscience·Dave J Hayes
Feb 28, 2015·ELife·Arpiar SaundersBernardo L Sabatini
Feb 4, 2016·The European Journal of Neuroscience·Daniel J HegemanC Savio Chan
May 29, 2016·Neuroscience and Biobehavioral Reviews·Carina Soares-CunhaAna J Rodrigues
Jun 1, 2016·Pediatric Obesity·C J de GrootJ van der Grond
Jun 23, 2016·The Journal of Comparative Neurology·Alexa R StephensonMary Ann Raghanti
Sep 1, 2016·CNS Neuroscience & Therapeutics·Chun-Ni GuoJun Lu
Sep 20, 2016·Neuroscience·Vania F PradoMarco A M Prado
Oct 5, 2016·Nature·Alexander M HermanBenjamin R Arenkiel
Oct 26, 2016·Current Biology : CB·Sten Grillner, Brita Robertson
Oct 27, 2015·PLoS Computational Biology·Mingming ChenDezhong Yao
Mar 18, 2017·Nature Reviews. Neuroscience·Christina K KimKarl Deisseroth
Nov 5, 2016·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Ajit Ranganath, Simon N Jacob
Feb 22, 2018·CNS Neuroscience & Therapeutics·Maurice GarretJérôme Baufreton
Jan 10, 2018·Frontiers in Neural Circuits·Giorgio Rizzi, Kelly R Tan
May 10, 2018·Annals of Neurology·Zhen NiRobert Chen
May 10, 2018·Annals of Neurology·Alberto CacciolaAngelo Quartarone
Jul 29, 2018·The European Journal of Neuroscience·Nicola Solari, Balázs Hangya

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