A direct protein-protein interaction is involved in the suppression of beta-catenin transcription by retinoid X receptor alpha in colorectal cancer cells

Cancer Biology & Therapy
Anjia HanWancai Yang

Abstract

Using both mammalian two-hybrid assay in vivo and immunoprecipitation in vitro we found that retinoid X receptor alpha (RXR alpha) directly interacted with beta-catenin and suppressed beta-catenin transcription activity and protein expression in colorectal cancer cells. But, reduction of RXR alpha by small interfering RNA upregulated beta-catenin transcriptional activity and protein expression. However, gain- or loss-expression of beta-catenin did not affect RXR alpha. Therefore, our data provided the first evidence tht RXR alpha directly interacted with beta-catenin and regulated beta-catenin transcription, which provides important information for developing novel strategies in colorectal cancer prevention by targeting RXR alpha-beta-catenin signaling.

Citations

May 6, 2009·Clinical and Experimental Pharmacology & Physiology·Xiuli BiWancai Yang
Aug 14, 2009·PloS One·Dong HuWancai Yang
Feb 19, 2015·Journal of Bone and Mineral Metabolism·Michela BosettiMario Cannas
Oct 27, 2015·Frontiers in Oncology·Shubhankar SumanKamal Datta
Sep 3, 2016·Scientific Reports·Renate GehwolfAndreas Traweger

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