A direct role for Hsp90 in pre-RISC formation in Drosophila.

Nature Structural & Molecular Biology
Tomohiro MiyoshiMikiko C Siomi

Abstract

Heat-shock proteins (Hsps) are molecular chaperones that control protein folding and function. Argonaute 2 (Ago2), the effector in RNA interference (RNAi), is associated with Hsp90; however, its function in RNAi remains elusive. Here we show that Hsp90 is required for Ago2 to receive the small interfering RNA (siRNA) duplex from the RNA-induced silencing complex-loading complex in RNAi, suggesting a model where Hsp90 modifies Ago2 conformation to accommodate the siRNA duplex.

References

Dec 1, 1995·Molecular and Cellular Biology·D F SmithR A Rimerman
Mar 24, 2004·Cell·Yukihide TomariPhillip D Zamore
Jul 31, 2004·Science·Jidong LiuGregory J Hannon
Nov 20, 2004·Science·Yukihide TomariPhillip D Zamore
Apr 1, 2005·Nature Structural & Molecular Biology·Fabiola V RivasLeemor Joshua-Tor
Nov 17, 2005·Genes & Development·Keita MiyoshiMikiko C Siomi
Dec 17, 2005·Genes & Development·Elisavet Maniataki, Zissimos Mourelatos
Jan 23, 2009·Nature·Haruhiko Siomi, Mikiko C Siomi
Jan 24, 2009·Nature Reviews. Molecular Cell Biology·V Narry KimMikiko C Siomi
May 22, 2009·Molecular Biology of the Cell·Justin M PareTom C Hobman
Dec 8, 2009·Nature Structural & Molecular Biology·Mayuko YodaYukihide Tomari
Mar 20, 2010·Molecular Biology of the Cell·Michael JohnstonGyorgy Hutvagner
Apr 17, 2010·Trends in Biochemical Sciences·Tomoko Kawamata, Yukihide Tomari

❮ Previous
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Citations

Dec 1, 2010·Nature Reviews. Genetics·Benjamin Czech, Gregory J Hannon
Jun 26, 2013·Nature Reviews. Genetics·Maartje J Luteijn, René F Ketting
May 10, 2011·Nature Structural & Molecular Biology·Xuecheng YeHong Zhang
Jan 12, 2012·Nature Structural & Molecular Biology·Pieter Bas Kwak, Yukihide Tomari
Jan 29, 2013·Nature Structural & Molecular Biology·Eneida A ParizottoJames S Parker
May 28, 2013·Nature Structural & Molecular Biology·Peter SmibertEric C Lai
May 18, 2011·Proceedings of the National Academy of Sciences of the United States of America·Shuo GuMark A Kay
Sep 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Xiao-Peng XiongRui Zhou
Mar 29, 2013·Genes & Development·Katsutomo OkamuraEric C Lai
Dec 25, 2010·The Plant Cell·Allison Mallory, Hervé Vaucheret
Nov 23, 2011·RNA·Juan G Betancur, Yukihide Tomari
Jul 4, 2012·RNA·Jonathan B PreallGregory J Hannon
Mar 28, 2013·RNA·Cameron L Noland, Jennifer A Doudna
Mar 15, 2013·RNA·Natalia J Martinez, Richard I Gregory
Feb 15, 2015·Molecular Plant·Cláudia MartinhoElena Baena-González
Jan 5, 2013·Trends in Cell Biology·Ritwick Sawarkar, Renato Paro
Jul 19, 2011·Current Opinion in Genetics & Development·Hirotsugu IshizuHaruhiko Siomi
Aug 26, 2015·Biochimica Et Biophysica Acta·Hotaka Kobayashi, Yukihide Tomari
Sep 19, 2015·Nucleic Acids Research·June Hyun Park, Chanseok Shin
May 29, 2013·Molecular Reproduction and Development·Sneha Ramesh Mani, Celina E Juliano
Nov 3, 2011·The EMBO Journal·Taichiro IkiMasayuki Ishikawa
Mar 21, 2013·The EMBO Journal·Lukas StalderNicole C Meisner-Kober
Aug 11, 2015·Molecular Cell·Chunyang LiangQinghua Liu
Nov 27, 2014·Bioengineered·Raja Sekhar NandetyBryce W Falk
Sep 12, 2015·Gene·Michael Haase, Guido Fitze
Sep 2, 2014·Molecular Cell·Xuhang LiuZissimos Mourelatos
Jul 6, 2013·Biochimica Et Biophysica Acta·Yang WangPaul LaPointe
Sep 29, 2011·Biochimica Et Biophysica Acta·Taras Makhnevych, Walid A Houry
May 31, 2011·Veterinary Parasitology·Zhancheng TianJin Luo
Oct 11, 2011·Biochimica Et Biophysica Acta·Veronika HaslbeckKlaus Richter
Mar 29, 2011·Biochemical and Biophysical Research Communications·Ken MatsumotoYasufumi Minami
Jun 10, 2011·Communicative & Integrative Biology·Barry R PittendrighJohn M Clark
Jul 17, 2012·Current Biology : CB·Shuo GuMark A Kay
Aug 19, 2014·Trends in Biochemical Sciences·Daniel Schraivogel, Gunter Meister
Jul 6, 2011·Molecular Cell·Cameron L NolandJennifer A Doudna
Apr 17, 2012·Molecular Cell·Xuhang LiuZissimos Mourelatos
Feb 6, 2015·Nucleic Acids Research·Yanwen GuoJun Lu
Jun 25, 2014·Frontiers in Genetics·Li-Ling Chak, Katsutomo Okamura

❮ Previous
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