PMID: 16532951Mar 15, 2006Paper

A direct voxel tracking method for four-dimensional Monte Carlo dose calculations in deforming anatomy

Medical Physics
Emily Heath, Jan Seuntjens

Abstract

In this work we present a method of calculating dose in deforming anatomy where the position and shape of each dose voxel is tracked as the anatomy changes. The EGSnrc/DOSXYZnrc Monte Carlo code was modified to calculate dose in voxels that are deformed according to deformation vectors obtained from a nonlinear image registration algorithm. The defDOSXYZ code was validated by consistency checks and by comparing calculations against DOSXYZnrc calculations. Calculations in deforming phantoms were compared with a dose remapping method employing trilinear interpolation. Dose calculations with the deforming voxels agree with DOSXYZnrc calculations within 1%. In simple deforming rectangular phantoms the trilinear dose remapping method was found to underestimate the dose by up to 29% for a 1.0 cm voxel size within the field, with larger discrepancies in regions of steep dose gradients. The agreement between the two calculation methods improved with smaller voxel size and deformation magnitude. A comparison of dose remapping from Inhale to Exhale in an anatomical breathing phantom demonstrated that dose deformations are underestimated by up to 16% in the penumbra and 8% near the surface with trilinear interpolation.

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Citations

May 29, 2012·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·M B KakakhelJ V Trapp
Sep 11, 2009·Physics in Medicine and Biology·Hualiang Zhong, Jeffrey V Siebers
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Oct 10, 2008·Medical Physics·Jeffrey V Siebers, Hualiang Zhong
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