A discrete mesoscopic particle model of the mechanics of a multi-constituent arterial wall

Journal of the Royal Society, Interface
Alexandra WitthoftGeorge Em Karniadakis

Abstract

Blood vessels have unique properties that allow them to function together within a complex, self-regulating network. The contractile capacity of the wall combined with complex mechanical properties of the extracellular matrix enables vessels to adapt to changes in haemodynamic loading. Homogenized phenomenological and multi-constituent, structurally motivated continuum models have successfully captured these mechanical properties, but truly describing intricate microstructural details of the arterial wall may require a discrete framework. Such an approach would facilitate modelling interactions between or the separation of layers of the wall and would offer the advantage of seamless integration with discrete models of complex blood flow. We present a discrete particle model of a multi-constituent, nonlinearly elastic, anisotropic arterial wall, which we develop using the dissipative particle dynamics method. Mimicking basic features of the microstructure of the arterial wall, the model comprises an elastin matrix having isotropic nonlinear elastic properties plus anisotropic fibre reinforcement that represents the stiffer collagen fibres of the wall. These collagen fibres are distributed evenly and are oriented in four directio...Continue Reading

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Jun 1, 2010·Computer Methods in Applied Mechanics and Engineering·Dmitry A FedosovGeorge Em Karniadakis

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Citations

Jun 8, 2017·Frontiers in Physiology·Pavel S ZunAlfons G Hoekstra
Jul 7, 2017·Journal of the Royal Society, Interface·N B MelnikovaA G Hoekstra

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