A disposable sampling device to collect volume-measured DBS directly from a fingerprick onto DBS paper

Bioanalysis
Gabriel LenkNiclas Roxhed

Abstract

DBS samples collected from a fingerprick typically vary in volume and homogeneity and hence make an accurate quantitative analysis of DBS samples difficult. We report a prototype which first defines a precise liquid volume and subsequently stores it to a conventional DBS matrix. Liquid volumes of 2.2 µl ± 7.1% (n = 21) for deionized water and 6.1 µl ± 8.8% (n = 15) for whole blood have been successfully metered and stored in DBS paper. The new method of collecting a defined volume of blood by DBS sampling has the potential to reduce assay bias for the quantitative evaluation of DBS samples while maintaining the simplicity of conventional DBS sampling.

References

Jul 30, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Patrick Beaudette, Kevin P Bateman
Jun 14, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Matt BarfieldSusan Fowles
Apr 8, 2009·Therapeutic Drug Monitoring·Peter M EdelbroekLeo M L Stolk
Nov 19, 2010·Bioanalysis·Peter van Amsterdam, Clare Waldrop
Sep 29, 2011·Journal of the American Society for Mass Spectrometry·Nicholas Edward ManickeR Graham Cooks

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Citations

Sep 4, 2015·Bioanalysis·Gabriel LenkNiclas Roxhed
Aug 23, 2019·Journal of Inherited Metabolic Disease·Stuart J MoatRachel S Carling
Apr 7, 2018·Analytical and Bioanalytical Chemistry·Ricardo NetoFlorian Lapierre
Nov 8, 2018·Analytical and Bioanalytical Chemistry·Sofia SoaresEugenia Gallardo
Oct 10, 2020·Lab on a Chip·Janosch HauserNiclas Roxhed
Oct 20, 2020·International Journal of Neonatal Screening·Stuart J MoatRachel S Carling
Feb 10, 2021·International Journal of Neonatal Screening·Stuart J MoatRachel S Carling
Jan 21, 2021·Therapeutic Drug Monitoring·Lisa DelahayeChristophe Stove
Mar 7, 2021·Therapeutic Drug Monitoring·Phillip Edgar Morgan
Nov 1, 2018·Analytical Chemistry·Janosch HauserNiclas Roxhed
May 8, 2019·Analytical Chemistry·Janosch HauserNiclas Roxhed
Sep 3, 2021·Bioanalysis·Vera de KleijneMariëtte T Ackermans

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