PMID: 1214227Dec 1, 1975Paper

A dissociation between fever and prostaglandin concentration in cerebrospinal fluid

The Journal of Physiology
W I CranstonD Mitchell

Abstract

1. Sustained fever has been induced in conscious rabbits by I.V. injection and infusion of endogenous pyrogen. 2. Cerebrospinal fluid (e.s.f.) was sampled from the cisterna magna at hourly intervals. The concentration of prostaglandin increased in parallel with rectal temperature. The prostaglandin was identified as one of the E series. 3. When sodium salicylate (1-5 m-mole followed by a continuous infusion of 9 mumole/min) was started 1 hr before endogenous pyrogen, the febrile response to the pyrogen was not significantly diminished but no rise of prostaglandin concentration was detected in c.s.f. 4. This dissociation between fever and prostaglandin concentration means that changes in cisternal prostaglandin concentration cannot be accepted as evidence that prostaglandin mediates the febrile response.

Citations

Jan 1, 1988·European Journal of Applied Physiology and Occupational Physiology·C Wenzel, J Werner
Jan 1, 1982·Pharmacology & Therapeutics·R Hellon, Y Townsend
May 1, 1982·The American Journal of Medicine·C A Dinarello, S M Wolff
Mar 1, 1980·British Journal of Pharmacology·J D PickardA Strathdee
Sep 1, 1981·Journal of Neurochemistry·C A Dinarello, H A Bernheim
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J D Pickard
Sep 1, 1985·Pflügers Archiv : European journal of physiology·M HashimotoM Iriki
Nov 1, 1977·Postgraduate Medical Journal·E MarleyJ D Stephenson
Mar 11, 1977·Pflügers Archiv : European journal of physiology·J A SplawińskiJ Kaluza
Feb 1, 1978·British Journal of Pharmacology·W G Clark, J A Robins
Jan 1, 1985·Pharmacology & Therapeutics·C G Van ArmanD H Kim
Jan 1, 1993·Neuroscience and Biobehavioral Reviews·H Moltz

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