A distinctive vesiculopustular eruption associated with hepatobiliary disease

International Journal of Dermatology
C M Magro, A N Crowson

Abstract

Cutaneous manifestations of hepatobiliary disease may be a clue to the clinical diagnosis. We encountered a form of vesiculopustular eruption in five patients with hepatobiliary disease. A similar eruption has been described in the setting of ulcerative colitis, and has received the designation of vesiculopustular pyoderma gangrenosum. Skin biopsy specimens were examined by conventional histopathologic methods and, in three cases, fresh tissue was available for direct immunofluorescence examination. A diagnosis of hepatobiliary disease was known in three of the patients and in the other two it was established by the skin biopsies. All skin biopsies of the five patients showed a neutrophilic dermatosis that had two morphologies. One was characterised by superficial neutrophilic dermolysis with subepidermal bulla formation and the other by a nonulcerating destructive suppurative folliculitis and perifollicular neutrophilic dermolysis. Both were frequently accompanied by a neutrophilic and lymphotic eccrine hidradermitis and a Sweet's syndrome-like vascular reaction. The lesions were held to represent a novel vesiculopustular eruption with features reminiscent of pyoderma gangrenosum. We propose the term vesiculopustular eruption ...Continue Reading

Citations

May 2, 2000·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A Geusau
Jul 28, 2007·Orphanet Journal of Rare Diseases·Philip R Cohen
May 7, 2010·European Journal of Pediatrics·Mi Jin Kim, Yon Ho Choe
Oct 3, 2003·International Journal of Dermatology·Philip R Cohen, Razelle Kurzrock
Dec 6, 2005·Clinics in Dermatology·Sharareh Ahmadi, Frank C Powell
Jul 16, 2005·Journal of the American Academy of Dermatology·Jörg ReichrathWolfgang Tilgen
Oct 31, 2001·Journal of the European Academy of Dermatology and Venereology : JEADV·M Goreti CatorzeF Assis Pacheco
Feb 26, 2000·International Journal of Dermatology·C M Magro, A N Crowson
Mar 19, 2003·Journal of Cutaneous Pathology·A Neil CrowsonCynthia Magro
Feb 2, 2018·Annals of Dermatology·Hye Rin YouSeung-Chul Lee
Dec 24, 2005·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Curdin Conrad, Ralph M Trüeb

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