PMID: 7515145Jan 1, 1994Paper

A disturbance of interferon synthesis with the hyperproduction of unusual kinds of interferon can trigger autoimmune disease and play a pathogenetic role in AIDS: the removal of these interferons can be therapeutic

Medical Hypotheses
Simon SkurkovichJ A Bellanti

Abstract

Disturbances of interferon synthesis with the hyperproduction of unusual kinds of interferons may be the initial step which triggers autoimmune disease through a chain of pathological reactions including the disturbances of several immunological and cytokine cascades. Prolonged circulation of this interferon may be a predictive marker of an autoimmune condition; the administration of interferons to animals or humans with autoimmune disease or an underlying or latent autoimmune condition can exacerbate or trigger the disease. Healthy people do not have interferon in their blood. This fundamental disturbance of interferon synthesis can result either from a genetic predisposition or from the influence of certain viruses (or viral particles) or both factors together. AIDS has many features similar to autoimmune disease, including the hyperproduction of aberrant interferon, a type with restricted anti-HIV activity, protectively induced by HIV to allow its continued replication and survival. This interferon stimulates the production of certain cytokines and autoantibodies which help unleash the potentially self-destructive powers of the immune system, bringing immunological chaos. In other words, while usual viruses induce normal int...Continue Reading

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Citations

Feb 10, 2009·Medical Hypotheses·Yajie LvTianwen Gao
Aug 30, 2005·Annals of the New York Academy of Sciences·Simon Skurkovich, Boris Skurkovich
May 1, 2005·Expert Review of Clinical Immunology·Simon SkurkovichJeanne Kelly
Mar 29, 2014·Eye·O M Uhumwangho, S Jalali
Aug 10, 2000·Journal of Marital and Family Therapy·D A RatliffG H Morris
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·J Brynskov, S N Rasmussen
Jul 23, 2003·AIDS·Peter F Currie, Nicholas A Boon

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