A Diverse Range of Novel RNA Viruses in Geographically Distinct Honey Bee Populations

Journal of Virology
Emily J RemnantAlyson Ashe

Abstract

Understanding the diversity and consequences of viruses present in honey bees is critical for maintaining pollinator health and managing the spread of disease. The viral landscape of honey bees (Apis mellifera) has changed dramatically since the emergence of the parasitic mite Varroa destructor, which increased the spread of virulent variants of viruses such as deformed wing virus. Previous genomic studies have focused on colonies suffering from infections by Varroa and virulent viruses, which could mask other viral species present in honey bees, resulting in a distorted view of viral diversity. To capture the viral diversity within colonies that are exposed to mites but do not suffer the ultimate consequences of the infestation, we examined populations of honey bees that have evolved naturally or have been selected for resistance to Varroa This analysis revealed seven novel viruses isolated from honey bees sampled globally, including the first identification of negative-sense RNA viruses in honey bees. Notably, two rhabdoviruses were present in three geographically diverse locations and were also present in Varroa mites parasitizing the bees. To characterize the antiviral response, we performed deep sequencing of small RNA pop...Continue Reading

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Datasets Mentioned

BETA
KY354242
KY354241
KY354243
KY354244
ARO50053
KY354230
KY354233
KY354234
KY354236
KY354237

Methods Mentioned

BETA
reverse transcription-PCR
PCR

Software Mentioned

RStudio
PhyML Interface ( MPI
TrimAL
ProtTest
Bowtie2
Samtools
viRome
MAFFT
Trinity
CLC Genomics Workbench

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