A division in PIN-mediated auxin patterning during organ initiation in grasses

PLoS Computational Biology
Devin O'ConnorSarah Hake


The hormone auxin plays a crucial role in plant morphogenesis. In the shoot apical meristem, the PIN-FORMED1 (PIN1) efflux carrier concentrates auxin into local maxima in the epidermis, which position incipient leaf or floral primordia. From these maxima, PIN1 transports auxin into internal tissues along emergent paths that pattern leaf and stem vasculature. In Arabidopsis thaliana, these functions are attributed to a single PIN1 protein. Using phylogenetic and gene synteny analysis we identified an angiosperm PIN clade sister to PIN1, here termed Sister-of-PIN1 (SoPIN1), which is present in all sampled angiosperms except for Brassicaceae, including Arabidopsis. Additionally, we identified a conserved duplication of PIN1 in the grasses: PIN1a and PIN1b. In Brachypodium distachyon, SoPIN1 is highly expressed in the epidermis and is consistently polarized toward regions of high expression of the DR5 auxin-signaling reporter, which suggests that SoPIN1 functions in the localization of new primordia. In contrast, PIN1a and PIN1b are highly expressed in internal tissues, suggesting a role in vascular patterning. PIN1b is expressed in broad regions spanning the space between new primordia and previously formed vasculature, suggesting...Continue Reading

Associated Protocols


Apr 25, 2014·Molecular Biology and Evolution·Tom BennettC Jill Harrison
Jan 25, 2016·Current Opinion in Plant Biology·Cara L SoyarsZachary L Nimchuk
Dec 3, 2014·Current Biology : CB·Tom BennettC Jill Harrison
Sep 24, 2015·Annual Review of Genetics·Elizabeth A Kellogg
Aug 8, 2015·Current Opinion in Plant Biology·Cyril LavedrineTeva Vernoux
Jun 9, 2015·Trends in Plant Science·Tom Bennett
Jun 28, 2015·Journal of Experimental Botany·Mikolaj CieslakPrzemyslaw Prusinkiewicz
Jun 2, 2015·Frontiers in Plant Science·Toshiaki TameshigeNaoyuki Uchida
Oct 30, 2014·Frontiers in Plant Science·Madelaine E Bartlett, Beth Thompson
Aug 1, 2014·Frontiers in Plant Science·Maura Cardarelli, Valentina Cecchetti
Sep 2, 2014·Frontiers in Plant Science·Sara BalzanNicola Carraro
May 21, 2016·Wiley Interdisciplinary Reviews. Developmental Biology·Carlos S Galvan-AmpudiaTeva Vernoux
Apr 19, 2017·Nature Plants·Richard Sibout
Jan 12, 2016·Current Opinion in Plant Biology·Michael W Lewis, Sarah Hake
Mar 2, 2017·The New Phytologist·Adam RunionsPrzemyslaw Prusinkiewicz
Jul 15, 2017·Plant, Cell & Environment·Vanesa B TognettiMónika Hrtyan
Jun 28, 2018·The New Phytologist·Alja van der SchurenChristian S Hardtke
Aug 15, 2018·The New Phytologist·Phillip A ConklinMichael J Scanlon
Oct 29, 2018·The New Phytologist·Dhinesh Kumar, Elizabeth A Kellogg
Sep 13, 2018·Annual Review of Genetics·Olga V SedelnikovaJane A Langdale
Dec 27, 2018·Plants·Annis E Richardson, Sarah Hake
Nov 27, 2018·Journal of Integrative Plant Biology·Neil J ShirleyMatthew R Tucker
Apr 19, 2019·PLoS Computational Biology·Félix P HartmannCris Kuhlemeier
May 8, 2019·Journal of Experimental Botany·Jorge LoraMathew R Tucker
Jul 28, 2019·The Plant Journal : for Cell and Molecular Biology·Karel MüllerJan Petrášek
Aug 15, 2019·Plant & Cell Physiology·Yong LiChuanzao Mao
Apr 15, 2020·The New Phytologist·Sree Janani RavichandranEnrico Scarpella
Apr 26, 2015·Journal of Experimental Botany·María Jazmín Abraham JuárezJune Simpson
Oct 21, 2015·PLoS Computational Biology·Graeme Mitchison
Feb 9, 2017·ELife·Alexandra B RebochoEnrico Coen
Feb 14, 2018·Development·Neha Bhatia, Marcus G Heisler
Oct 9, 2019·Annual Review of Cell and Developmental Biology·Andrew Muroyama, Dominique Bergmann
Jan 10, 2017·Frontiers in Plant Science·Alejandro Morales-Tapia, Alfredo Cruz-Ramírez
Sep 29, 2020·Molecular Biology and Evolution·Siddharth KulkarniGustavo Hormiga


Jan 1, 1968·International Archives of Allergy and Applied Immunology·M D CooperR A Good
Apr 13, 2000·The Plant Cell·D ReinhardtCris Kuhlemeier
Jun 1, 1992·The Plant Cell·J. I. MedfordK. A. Feldmann
Nov 25, 2003·Nature·Didier ReinhardtCris Kuhlemeier
Nov 22, 2005·The Plant Journal : for Cell and Molecular Biology·Anne-Gaëlle Rolland-Lagan, Przemyslaw Prusinkiewicz
Jan 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Henrik JönssonEric Mjolsness
Jan 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Richard S SmithPrzemyslaw Prusinkiewicz
Apr 8, 2006·Science·Jan PetrášekJiří Friml
Apr 8, 2006·Science·Justyna WisniewskaJiří Friml
Apr 19, 2006·Genes & Development·Enrico ScarpellaThomas Berleth
Sep 4, 2007·Trends in Plant Science·Roeland M H MerksGerrit T S Beemster
Mar 19, 2008·Genes & Development·Katherine BainbridgeCris Kuhlemeier
Jun 14, 2008·Plant Physiology·Andrea GallavottiDavid Jackson
Feb 11, 2009·Genes & Development·Emmanuelle M BayerCris Kuhlemeier
Apr 24, 2009·Trends in Plant Science·Eric M Kramer
May 9, 2009·PLoS Genetics·Lionel BrooksMichael J Scanlon
May 21, 2009·Plant, Cell & Environment·Richard S Smith, Emmanuelle M Bayer
Jul 28, 2009·Development·Jan Petrášek, Jiří Friml
Jan 8, 2010·Genome Biology·Pavel KrecekEva Zazímalová
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jing ZhangJiří Friml
Jul 14, 2010·Plant Signaling & Behavior·George Chuck, Esteban Bortiri
Feb 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Gemma D BilsboroughMiltos Tsiantis
May 10, 2011·Current Biology : CB·Ottoline Leyser
Jun 15, 2011·Trends in Plant Science·Krzysztof WabnikJiří Friml
Jul 2, 2011·The Plant Cell·Michael Sauer, Jürgen Kleine-Vehn
Oct 4, 2011·Current Opinion in Cell Biology·Jan Dettmer, Jiří Friml
Jan 13, 2012·The New Phytologist·Przemyslaw Prusinkiewicz, Adam Runions
May 29, 2012·Frontiers in Plant Science·Cristian ForestanSerena Varotto
Sep 18, 2012·Trends in Plant Science·Tom ViaeneJiří Friml
Jan 29, 2013·Plant Physiology·Paul Derbyshire, Mary E Byrne

Related Concepts

Carica papaya
Establishment and Maintenance of Localization
In Silico
PIN1 gene
Plant Carpals
Projections and Predictions
Entire Vein

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.