A DNA-Methylated Sight on Autoimmune Inflammation Network across RA, pSS, and SLE

Journal of Immunology Research
Xingqiang WangJian Xu

Abstract

Methylation variabilities of inflammatory cytokines play important roles in the development of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and primary Sjögren's syndrome (pSS). With heightened focus on personalized and precise medicine, it is necessary to compare and contrast the difference and similarity of cytokine methylation status between the 3 most classic autoimmune diseases (AIDs). In this study, we integrated 5 Cytokine-Chips from genome-wide DNA methylation datasets of the 3 kind of AIDs, delta-beta value was calculated for intergroup difference, and comprehensive bioinformatics analyses of cytokine genes with aberrant methylations were performed. 125 shared differential methylation variabilities (DMVs) were identified. There were 102 shared DMVs with similar methylation status; 3 hypomethylated differential methylation regions (DMRs) across the AIDs were found, and all 3 DMRs were hypomethylated. DMRs (AZU1, LTBR, and RTEL1) were likely to serve as activator in the inflammatory process. Particularly, AZU1 and LTBR with hypomethylated TSS and first exon located in the promoter regions were able to trigger inflammation signaling cascades and play critical roles in autoimmune tautology. Moreover, func...Continue Reading

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Citations

Jun 6, 2020·European Journal of Immunology·Sandra C Silva-CardosoAridaman Pandit
Apr 1, 2021·BMC Pregnancy and Childbirth·Qian ChenJun Zhang

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Datasets Mentioned

BETA
GSE42861

Methods Mentioned

BETA
methylation profiling
chip
antisense oligonucleotide

Software Mentioned

FANTOM
R
Cytokine
dmpFinder
minfi
R package “ ChAMP ”
Bioconductor
clusterProfiler
DMRcate
FEM

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