PMID: 9440508Jan 24, 1998Paper

A DnaK homolog in Myxococcus xanthus is involved in social motility and fruiting body formation

Journal of Bacteriology
Z YangW Shi

Abstract

Myxococcus xanthus is a gram-negative soil bacterium which exhibits a complex life cycle and social behavior. In this study, two developmental mutants of M. xanthus were isolated through Tn5 transposon mutagenesis. The mutants were found to be defective in cellular aggregation as well as in sporulation. Further phenotypic characterization indicated that the mutants were defective in social motility but normal in directed cell movements. Both mutations were cloned by a transposon-tagging method. Sequence analysis indicated that both insertions occurred in the same gene, which encodes a homolog of DnaK. Unlike the dnaK genes in other bacteria, this M. xanthus homolog appears not to be regulated by temperature or heat shock and is constitutively expressed during vegetative growth and under starvation. The defects of the mutants indicate that this DnaK homolog is important for the social motility and development of M. xanthus.

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Citations

Oct 10, 2001·Journal of Bacteriology·M OtaniS Inouye
Feb 15, 2002·Journal of Bacteriology·Hope LanceroLawrence J Shimkets
Apr 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yinuo LiWenyuan Shi
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Aug 10, 2020·Biological Chemistry·María Pérez-Burgos, Lotte Søgaard-Andersen
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Apr 15, 2017·Cellular and Molecular Life Sciences : CMLS·Abu Iftiaf Md Salah Ud-Din, Anna Roujeinikova
Aug 30, 2021·Molecular Microbiology·Fares SaïdiSalim T Islam

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