Abstract
African green monkey (AGM) tripartite motif protein (TRIM) 5alpha can inhibit both human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus SIVmac, whereas cynomolgus monkey (CM) TRIM5alpha can inhibit HIV-1, but not SIVmac. We previously reported that the 17-amino-acid region and an adjacent 20-amino-acid duplication in the SPRY(B30.2) domain of AGM TRIM5alpha determined the species specificity. In the present study, we demonstrated that CM TRIM5alpha had a dominant-negative effect on the anti-SIVmac activity of AGM TRIM5alpha. In contrast, mutant TRIM5alphas lacking the 20-amino-acid duplication did not have the dominant-negative effect, even though they failed to restrict SIVmac. These results indicated that oligomerization of the SPRY domain is required for anti-SIVmac activity and suggest that tight interaction between the viral capsid and all three molecules in one TRIM5alpha trimer may not be necessary for restriction activity.
References
Nov 1, 1995·The Journal of General Virology·R ShibataA Adachi
May 15, 1996·Virology·S Himathongkham, P A Luciw
May 2, 2001·The EMBO Journal·A ReymondA Ballabio
Feb 27, 2004·Nature·Matthew StremlauJoseph Sodroski
Jul 10, 2004·Nature·David M SayahJeremy Luban
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Theodora HatziioannouPaul D Bieniasz
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Zuzana KeckesovaGreg J Towers
Jul 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Melvyn W YapJonathan P Stoye
Jul 29, 2004·Proceedings of the National Academy of Sciences of the United States of America·Michel J PerronJoseph Sodroski
Aug 25, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sébastien NisoleMelvyn W Yap
Jan 15, 2005·Current Biology : CB·Melvyn W YapJonathan P Stoye
Feb 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sara L SawyerHarmit S Malik
Feb 15, 2005·Journal of Virology·Matthew StremlauJoseph Sodroski
May 28, 2005·Journal of Virology·Lionel BerthouxJeremy Luban
Jul 5, 2005·Journal of Virology·Emi E NakayamaTatsuo Shioda
Jul 5, 2005·Journal of Virology·David Perez-CaballeroPaul D Bieniasz
Sep 27, 2005·Virology·Byeongwoon SongJoseph Sodroski
Oct 29, 2005·Journal of Virology·Claudia C MischeJoseph Sodroski
Citations
Sep 10, 2010·Retrovirology·Ken KonoEmi E Nakayama
Apr 5, 2007·Immunogenetics·Emi E NakayamaIoannis Theodorou
Jun 6, 2008·Journal of Virological Methods·Hikoichiro MaegawaTatsuo Shioda
Jan 6, 2010·Reviews in Medical Virology·Emi E Nakayama, Tatsuo Shioda
Mar 15, 2013·The Journal of General Virology·Akatsuki SaitoHirofumi Akari
Sep 16, 2015·AIDS·Emi E Nakayama, Tatsuo Shioda
Jan 19, 2008·Virology·Ken KonoEmi E Nakayama
Apr 4, 2009·Virology·Ken KonoEmi E Nakayama
Dec 1, 2012·Cellular Reprogramming·Stephanie WunderlichUlrich Martin
May 1, 2018·Science China. Life Sciences·Dan MuYong-Tang Zheng
May 16, 2020·Frontiers in Bioengineering and Biotechnology·Mai IzumidaYoshinao Kubo