PMID: 9535130Apr 16, 1998Paper

A dopamine-synthesizing cell group demonstrated in the human basal forebrain by dual labeling immunohistochemical technique of tyrosine hydroxylase and aromatic L-amino acid decarboxylase

Neuroscience Letters
K IkemotoR Arai

Abstract

The human basal forebrain has been known to contain many neurons immunoreactive (ir) to tyrosine hydroxylase (TH; the first dopamine-synthesizing enzyme). We examined whether these neurons might contain aromatic L-amino acid decarboxylase (AADC; the second step dopamine-synthesizing enzyme) by dual labeling immunohistochemistry and confocal laser-scanning microscopy. Neurons dually-labeled for TH and AADC were found in the anterior olfactory nucleus, olfactory tubercle and the ventral margin of the rostral nucleus accumbens. The examination in the basal forebrain of the macaque monkey also gave substantially the same results. These neurons appear to constitute an independent dopaminergic cell group in the primate basal forebrain.

References

Jan 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·M M Esiri, G K Wilcock
Jan 1, 1995·Experimental Brain Research·K IkemotoH C Fibiger
May 1, 1995·Movement Disorders : Official Journal of the Movement Disorder Society·R K PearceS E Daniel
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Citations

Apr 20, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Keiko Ikemoto
Sep 30, 2000·Brain Research. Brain Research Reviews·W J Smeets, A González
Aug 26, 2003·Legal Medicine·Keiko IkemotoKatsuji Nishi
Aug 3, 2000·Journal of Anatomy·W J SmeetsA González
May 10, 2018·Pigment Cell & Melanoma Research·Hanine BarekManickam Sugumaran
Dec 8, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·J Eric Ahlskog
Oct 13, 2021·Journal of Neural Transmission·P RiedererJ Sian-Hülsmann

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