A dopamine transporter polymorphism is a risk factor for borderline personality disorder in depressed patients

Psychological Medicine
Peter R JoyceMartin A Kennedy

Abstract

Borderline personality disorder (BPD) is often co-morbid with major depression and may complicate its treatment. We were interested in differences in genetic and developmental risk factors between depressed patients with or without a co-morbid BPD. Out-patients with major depressive disorder were recruited for two treatment trials. Assessment of depressed patients included the assessment of personality disorders, developmental risk factors and DNA samples for genetic analyses. In each study there was a significant association between the 9-repeat allele of the dopamine transporter (DAT1) and BPD, with odds ratios (OR) > 3 and p < or = 0.02. This association remained significant when developmental risk factors for BPD (childhood abuse and neglect and borderline temperament) were also included in the analyses. The OR was even larger in the depressed patients aged > or = 35 years (OR 9.31, p = 0.005). This replicated association in depressed patients between the 9-repeat allele of DAT1 and BPD may provide clues to understanding the neurobiology of BPD. The finding that the association is larger in the older depressed patients, suggests that the 9-repeat allele may be associated with a poorer prognosis BPD, rather than a young adul...Continue Reading

Citations

Oct 25, 2011·The Psychiatric Quarterly·Maria LucaCarmela Calandra
Mar 7, 2012·The Psychiatric Quarterly·Diomidis AntoniadisMiltos Livaditis
Oct 20, 2011·Current Psychiatry Reports·Andrew M Chanen, Michael Kaess
Feb 2, 2012·Development and Psychopathology·Daniel W BelskyTerrie E Moffitt
Apr 22, 2009·Psychological Bulletin·Sheila E CrowellMarsha M Linehan
Jan 25, 2014·Neuroscience and Biobehavioral Reviews·Ali AmadPhilip Gorwood
Oct 29, 2013·Schizophrenia Bulletin·Steven MarwahaDaniel Freeman
Oct 27, 2010·Behavioural Brain Research·Amber M MuehlmannDarragh P Devine
Sep 14, 2010·Clinics in Laboratory Medicine·Ted Reichborn-Kjennerud
Jul 22, 2008·The Psychiatric Clinics of North America·Ted Reichborn-Kjennerud
Jul 22, 2008·The Psychiatric Clinics of North America·Antonia S NewLarry J Siever
Jul 3, 2013·Journal of Psychiatric Research·Raffaella CalatiAlessandro Serretti
Jan 1, 2015·L'Encéphale·M MaurelJ-M Azorin
Apr 18, 2012·The Australian and New Zealand Journal of Psychiatry·Darryl Bassett
Feb 26, 2010·The Australian and New Zealand Journal of Psychiatry·Peter R JoyceMartin A Kennedy
Sep 11, 2007·The Australian and New Zealand Journal of Psychiatry·Peter R JoyceMartin A Kennedy
Mar 13, 2018·Current Opinion in Psychiatry·Iris E SommerKenneth Hugdahl
Aug 3, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Angélica Salatino-OliveiraMara H Hutz
Jan 24, 2018·Proceedings of the National Academy of Sciences of the United States of America·Mary Ann RaghantiC Owen Lovejoy
Mar 12, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Alexandra SchosserHarald N Aschauer
Sep 8, 2016·Harvard Review of Psychiatry·Anthony C Ruocco, Dean Carcone

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