A Dosimetric Comparison of Breast Radiotherapy Techniques to Treat Locoregional Lymph Nodes Including the Internal Mammary Chain

Clinical Oncology : a Journal of the Royal College of Radiologists
A RangerA Kirby

Abstract

Radiotherapy target volumes in early breast cancer treatment increasingly include the internal mammary chain (IMC). In order to maximise survival benefits of IMC radiotherapy, doses to the heart and lung should be minimised. This dosimetry study compared the ability of three-dimensional conformal radiotherapy, arc therapy and proton beam therapy (PBT) techniques with and without breath-hold to achieve target volume constraints while minimising dose to organs at risk (OARs). In 14 patients' datasets, seven IMC radiotherapy techniques were compared: wide tangent (WT) three-dimensional conformal radiotherapy, volumetric-modulated arc therapy (VMAT) and PBT, each in voluntary deep inspiratory breath-hold (vDIBH) and free breathing (FB), and tomotherapy in FB only. Target volume coverage and OAR doses were measured for each technique. These were compared using a one-way ANOVA with all pairwise comparisons tested using Bonferroni's multiple comparisons test, with adjusted P-values ≤ 0.05 indicating statistical significance. One hundred per cent of WT(vDIBH), 43% of WT(FB), 100% of VMAT(vDIBH), 86% of VMAT(FB), 100% of tomotherapy FB and 100% of PBT plans in vDIBH and FB passed all mandatory constraints. However, coverage of the IMC w...Continue Reading

Citations

Aug 27, 2019·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rachel B JimenezShannon M MacDonald
Nov 14, 2019·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·K J BormS E Combs
Mar 5, 2021·Clinical and Translational Radiation Oncology·Line Bjerregaard StickBirgitte Vrou Offersen
May 7, 2021·American Society of Clinical Oncology Educational Book·Samilia Obeng-GyasiKevin Kalinsky
May 29, 2021·International Journal of Radiation Oncology, Biology, Physics·Robert W MutterShannon M MacDonald
Jul 7, 2021·Clinical Oncology : a Journal of the Royal College of Radiologists·S SettatreeA Kirby
Jul 20, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·P LoapY Kirova
Jul 29, 2021·Journal of the National Cancer Institute·Philip M PoortmansUNKNOWN EORTC Radiation Oncology and Breast Cancer Groups
May 8, 2019·Clinical Oncology : a Journal of the Royal College of Radiologists·F K DuaneC W Taylor
Jul 20, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Cristina M DeCesarisElizabeth Nichols

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