A double-blind clinical trial with a lotion containing 5% benzoyl peroxide and 2% miconazole in patients with acne vulgaris

Clinical and Experimental Dermatology
J Mesquita-GuimarãesM R Carvalho


The therapeutic efficacy of a lotion containing 5% benzoyl peroxide and 2% miconazole was compared with 5% benzoyl peroxide alone, in a double-blind, randomized, parallel study. Thirty patients with comedonal or inflammatory acne vulgaris were enrolled. The medications were applied once daily during the first week, and then twice daily for the rest of the trial (45 days). In patients with comedonal acne there was no difference in the effect of the two therapies. In patients with inflammatory acne the percentage reduction of the number of lesions on Day 30 was significantly higher in the benzoyl peroxide plus miconazole group (66%) compared to benzoyl peroxide alone (37%). At Day 45 there was a trend favouring the combined therapy but the difference was not significant. There were no significant differences in the adverse reactions reported by the two groups of patients (erythema, itching or moderate exfoliation).


Jun 1, 1976·Antimicrobial Agents and Chemotherapy·K H SwamyG R Rao
Mar 1, 1977·Antimicrobial Agents and Chemotherapy·S De NollinMarcel Borgers
Apr 1, 1978·Chemico-biological Interactions·H van den BosscheL Le Jeune
Dec 1, 1979·Clinical and Experimental Dermatology·D G PitcherR H Seville
Aug 1, 1986·Antimicrobial Agents and Chemotherapy·D BarugA Kerkenaar
Jul 1, 1969·The British Journal of Dermatology·G W Beveridge, E W Powell
Jul 1, 1970·Archives of Dermatology·P E Weary
Jul 1, 1971·The Journal of Investigative Dermatology·T Ray, R E Kellum
May 1, 1972·The Journal of Investigative Dermatology·R E Kellum, K Strangfeld
Nov 1, 1972·Postgraduate Medicine·J E Fulton
Jan 1, 1980·The Journal of Investigative Dermatology·S B TuckerR E Jordon
Sep 1, 1982·The British Journal of Dermatology·H Vanden BosscheJ van Cutsem


Jan 5, 2010·Biological & Pharmaceutical Bulletin·Takashi SugitaAkemi Nishikawa
Nov 24, 2004·Clinics in Dermatology·Andrea Krautheim, Harald P M Gollnick
Jun 5, 2012·The Journal of Dermatological Treatment·Noor Hidayah Mohd Nor, Zoriah Aziz
Jul 17, 2008·Expert Opinion on Pharmacotherapy·Pascale QuatresoozGérald E Piérard
Sep 17, 2013·Revista Do Instituto De Medicina Tropical De São Paulo·Polianna L M M AlbuquerqueElizabeth F Daher
Mar 17, 2020·The Cochrane Database of Systematic Reviews·Zhirong YangQian Zhang

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.