PMID: 8459913Jan 1, 1993Paper

A double-blind, comparative study of gadodiamide injection and gadopentetate dimeglumine in MRI of the central nervous system

Neuroradiology
J ValkM G Svaland

Abstract

Seventy-nine patients with known or suspected central nervous system lesions were studied with MRI in a phase III double-blind study. Forty were given gadopentetate dimeglumine (Gd-DTPA) and 39 gadodiamide injection (Gd-DTPA BMA), a new low-osmolar nonionic contrast enhancing medium. The dosage was 0.1 mmol/kg body weight, corresponding to 0.2 ml/kg. Spin-echo sequences were performed before and immediately after injection. The safety and efficacy of the two contrast media were assessed. No changes were observed in blood pressure, heart rate or neurological status. Five adverse effects (two episodes of headaches, two of nausea and one of dizziness) were reported by 2 patients who received gadodiamide injection and 1 who received gadopentetate dimeglumine. All events were mild and their relationship to the contrast media was uncertain. For both contrast media statistically significant changes in serum iron were observed 24 h after injection. More than 70% of the patients had abnormal findings on MRI, and in 56% of these contrast enhancement of the abnormal structure or lesion was seen. Contrast enhancement provided the diagnosis in about 50%, changed it in 40% and increased diagnostic confidence in 95%.

Citations

Mar 16, 2004·European Radiology·M Essig
Nov 20, 2003·Topics in Magnetic Resonance Imaging : TMRI·Miles A Kirchin, Val M Runge
Mar 29, 2008·European Journal of Radiology·Aart J van der Molen, Marie-France Bellin
Mar 4, 2000·Lancet·Y Tsushima, K Endo
May 24, 2014·AJNR. American Journal of Neuroradiology·E KanalH A Rowley
Oct 1, 2010·The Neuroradiology Journal·M Essig, L Gerigk

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