A double-blind controlled trial of two dose levels of factor VIII in the treatment of high risk haemarthroses in haemophilia A

Clinical and Laboratory Haematology
A AronstamD S McLellan

Abstract

One hundred and thirteen haemarthroses involving the knees, ankles and elbows of 29 severe haemophiliacs presenting with at least two of the risk factors, pain, tenderness, loss of more than 50% of movement and a delay of more than 3 h in treatment were studied. Each was given either a 20% or 40% dose of factor VIII and progress was then reviewed by medical staff unaware of the initial dosage. There was no significant effect on the retransfusion rate nor on the time to complete resolution. However, the difference between the percentage of patients showing residual movement restriction was significantly in favour of the high dose at 24, 36 and 48 h when all the bleeds were pooled and at 48 h for elbow bleeds.

References

Jan 1, 1979·Lancet·R I Harris, J Stuart
Sep 1, 1979·Journal of Clinical Pathology·A AronstamP Turk
Mar 13, 1982·British Medical Journal·A AronstamZ Hamad
Jan 1, 1982·Clinical and Laboratory Haematology·A AronstamD L Aston
Mar 1, 1982·Journal of Clinical Pathology·A AronstamP S Mbatha

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Citations

Jun 28, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·M A Escobar
Jul 11, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·A SrivastavaUNKNOWN Treatment Guidelines Working Group on Behalf of The World Federation Of Hemophilia
Jun 25, 2014·European Journal of Haematology. Supplementum·Sonata Saulyte Trakymiene, Katarina Steen Carlsson
Feb 21, 2006·British Journal of Haematology·Paula H B Bolton-Maggs
Apr 4, 2017·Haemophilia : the Official Journal of the World Federation of Hemophilia·J HanleyUNKNOWN Musculoskeletal Working Party of the UKHCDO
Sep 24, 2004·British Journal of Haematology·Alok Srivastava

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