PMID: 43164Jan 1, 1979

A double-blind crossover comparison of pindolol, metoprolol, atenolol and labetalol in mild to moderate hypertension

British Journal of Clinical Pharmacology
J J McNeil, W J Louis


1 This study was designed to compare in a double-blind randomized crossover trial, atenolol, labetalol, metoprolol and pindolol. Considerable differences in dose (atenolol 138 +/- 13 mg daily; labetalol 308 +/- 34 mg daily; metoprolol 234 +/- 22 mg daily; and pindolol 24 +/-2 mg daily were required to produce similar antihypertensive effects. 3 The overall incidence of side-effects was similar with atenolol, metoprolol and pindolol but was slightly less with labetalol. Sleep disturbances and abnormal dreaming patterns were most frequent with pindolol. 4 There was a significantly greater fall in pulse rate during atenolol and metoprolol treatment periods.

Related Concepts

Physiologic Pulse
Sleep Disorders
Hypertensive Disease
Antihypertensive Agents

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

European Journal of Clinical Pharmacology
E C FoersterW Vetter
Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
A GordinS Sundberg
British Journal of Clinical Pharmacology
J KaneD A Richards
© 2020 Meta ULC. All rights reserved