PMID: 8942410Dec 1, 1996Paper

A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract and placebo administration on blood lipids

The American Journal of Clinical Nutrition
M SteinerR I Lin

Abstract

A double-blind crossover study comparing the effect of aged garlic extract with a placebo on blood lipids was performed in a group of 41 moderately hypercholesterolemic men [cholesterol concentrations 5.7-7.5 mmol/L (220-290 mg/dL)]. After a 4-wk baseline period, during which the subjects were advised to adhere to a National Cholesterol Education Program Step I diet, they were started on 7.2 g aged garlic extract per day or an equivalent amount of placebo as a dietary supplement for a period of 6 mo, then switched to the other supplement for an additional 4 mo. Blood lipids, blood counts, thyroid and liver function measures, body weight, and blood pressure were followed over the entire study period. The major findings were a maximal reduction in total serum cholesterol of 6.1% or 7.0% in comparison with the average concentration during the placebo administration or baseline evaluation period, respectively. Low-density-lipoprotein cholesterol was also decreased by aged garlic extract, 4% when compared with average baseline values and 4.6% in comparison with placebo period concentrations. In addition, there was a 5.5% decrease in systolic blood pressure and a modest reduction of diastolic blood pressure in response to aged garlic...Continue Reading

Citations

Dec 30, 1998·Current Opinion in Lipidology·H K Berthold, T Sudhop
Mar 10, 2001·The Journal of Nutrition·R S Rivlin
Jul 28, 2001·Nutrition Reviews·D Spigelski, P J Jones
Feb 26, 2003·Phytotherapy Research : PTR·S K BanerjeeS K Maulik
Feb 18, 2006·The Journal of Nutrition·Carmia Borek
Dec 12, 2012·Critical Reviews in Food Science and Nutrition·Tao ZengKe-Qin Xie
Apr 18, 2013·Nutrition Reviews·Karin RiedPeter Fakler
Apr 11, 2013·Journal of Food Science and Technology·Lipi DasRunu Chakraborty
Jul 12, 2019·Phytotherapy Research : PTR·Christian VlachojannisSigrun Chrubasik-Hausmann
Mar 10, 2001·The Journal of Nutrition·H AmagaseY Itakura
Aug 23, 2002·Anaesthesia·P J Hodges, P C A Kam
Nov 30, 2002·Phytotherapy Research : PTR·Nongluck SookvanichsilpPirin Yuennan
Oct 4, 2003·Current Atherosclerosis Reports·Christopher D GardnerJohn W Farquhar
Feb 21, 2007·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Jeffrey Knox, Barak Gaster
Dec 9, 2008·Journal of Atherosclerosis and Thrombosis·Igor A SobeninAlexander N Orekhov
Jun 27, 2009·Nutrition Research Reviews·Kurt M ReinhartCraig I Coleman
Aug 17, 2012·The Cochrane Database of Systematic Reviews·Sarah N StablerClaire Fowkes
Feb 22, 2012·ISRN Cardiology·Yaling YangBrian Tomlinson
Mar 13, 2014·The Journal of Obstetrics and Gynaecology Research·Mehranghiz Ebrahimi-MamaghaniMohammad Asghari-Jafarabadi
Sep 19, 2012·Current Diabetes Reports·Monica M DiNardoEdward S Lee
Feb 15, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Hirotaka AmanoYukihiro Kodera
Dec 19, 2016·Frontiers in Pharmacology·Cuiqing Liu, Yu Huang
Mar 10, 2001·The Journal of Nutrition·K Rahman
Mar 22, 2002·Clinical and Experimental Pharmacology & Physiology·David D KuGary A Abrams
Apr 20, 2001·Pharmacotherapy·M F Caron, C M White
Dec 13, 2006·The American Journal of Clinical Nutrition·Martijn B A van DoornJacobus Burggraaf
Jan 23, 2003·Nutrition Journal·Sanjay K Banerjee, Subir K Maulik
Mar 10, 2001·The Journal of Nutrition·H Matsuura
May 22, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Waris Qidwai, Tabinda Ashfaq
Jan 12, 2012·Journal of the Science of Food and Agriculture·Tao ZengKe-Qin Xie
Feb 19, 2016·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Hirotaka AmanoKenji Itoh
May 12, 2015·Journal of Immunology Research·Rodrigo ArreolaDaniel Ortuño-Sahagún
Jan 15, 2016·The Journal of Nutrition·Jessica M BradleyDavid J Lefer
Aug 2, 2002·Current Opinion in Lipidology·Penny M Kris-EthertonChristopher Gardner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.