PMID: 326847Jul 1, 1977Paper

A double-blind evaluation of the use of nebulized metaproterenol and isoproterenol in hospitalized asthmatic children and adolescents

The Journal of Allergy and Clinical Immunology
B GarraC W Bierman

Abstract

This study compared two beta-adrenergic agents in the treatment of severe asthma of children and adolescents. Thirty patients admitted to Children's Orthopedic Hospital and Medical Center with acute asthma were treated with either isoproterenol 0.05% (iso) or metaproterenol 0.5% (meta) nebulized in physiologic saline and delivered with O2 in addition to intravenous hydration, aminophylline, and corticosteroids. Vital signs, blood gases, and pulmonary function were monitored frequently. No adverse reactions to the study drugs were encountered. Pulse rates increased similarly after treatments with both drugs. Patients treated with meta had somewhat higher rates than those treated with iso. Diastolic blood pressure decreased significantly from admission in the meta group compared to the iso group. For FVC and FEV1, the meta group had greater percentage increases from admission than the iso group at all times, with the difference being significant (p less than 0.05) at 1 and 12 hr. The same trend occurred for FEF 25%-75%. Though iso seemed to cause greater increases in flow immediately after administrations, these changes were transient compared to improvement caused by meta. Thus, meta seemed to be more effective than iso in rever...Continue Reading

References

Aug 1, 1971·Archives of Disease in Childhood·A D Milner, D Ingram

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Citations

Feb 1, 1985·Clinical Reviews in Allergy·G Kurland, A B Leong
Jan 1, 1983·Digestive Diseases and Sciences·D Y GrahamS M Dobbs
Jul 1, 1985·Drug Intelligence & Clinical Pharmacy·R M ElenbaasM J Singsank
Jan 1, 1983·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·R S Zeiger
Jan 1, 1992·The Annals of Pharmacotherapy·H W Kelly, S Murphy
Jan 1, 1983·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·G G ShapiroC W Bierman

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