Jul 1, 1988

A double blind multicentre study of OM-8980 and auranofin in rheumatoid arthritis

Annals of the Rheumatic Diseases
T L Vischer


The therapeutic efficacy of the immunomodulator OM-8980 in rheumatoid arthritis was compared with that of auranofin, an oral gold salt, in a double blind, randomised multicentre study lasting six months. Seventy patients were treated with auranofin and 75 with OM-8980. The patients of both groups improved significantly at three and six months for all the clinical parameters observed: Ritchie index, number of swollen joints, morning stiffness, pain, grip strength, intake of non-steroidal anti-inflammatory drugs, and erythrocyte sedimentation rate. No serious side effects were observed in either group. The patients receiving auranofin had more adverse reactions, mainly affecting the gastrointestinal system.

Mentioned in this Paper

Alkalescens-Dispar Group
Immunologic Adjuvants
Erythrocyte Sedimentation Rate Measurement
Rheumatoid Arthritis
Steroidal anti-inflammatory drugs
Antigens, Bacterial
Entire Gastrointestinal System
Clinical Trials
Joint Swelling

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