Abstract
To compare the effectiveness of granisetron with placebo in the treatment of established postoperative nausea and vomiting (PONV). Randomized, placebo-controlled study. 34 hospitals in Europe, Scandinavia, and South Africa. 519 ASA physical status I, II, and III patients who developed PONV within 4 hours of the end of surgery performed with general anesthesia. Patients received a single intravenous dose of granisetron 0.1 mg, 1 mg, or 3 mg, or placebo when symptoms of nausea or vomiting were experienced. Additional rescue medication could be given at the investigator's discretion if nausea and vomiting were not controlled. At all doses investigated, granisetron was significantly more effective (p < or = 0.001) than placebo in controlling vomiting: 38%, 46%, and 49% of patients receiving granisetron, 0.1 mg, 1.0 mg, and 3.0 mg, respectively, experienced no vomiting in the first 24 hours following drug administration, compared with 20% receiving placebo. There was a statistically significant linear relationship between vomiting control and granisetron dose (p < 0.001). Survival distributions of time to resolution of vomiting confirmed the statistically significant difference between patients receiving granisetron and those receiv...Continue Reading
References
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M Marty
May 1, 1992·British Journal of Anaesthesia·G N KennyC G Haigh
Jan 1, 1992·British Journal of Anaesthesia·J Lerman
Jul 1, 1992·Anesthesiology·M F Watcha, P F White
Sep 1, 1991·Anesthesia and Analgesia·G E LarijaniS Minassian
Sep 1, 1991·Anesthesia and Analgesia·M Bodner, P F White
Aug 1, 1986·British Journal of Anaesthesia·T H Madej, K H Simpson
Jan 1, 1994·Anaesthesia·M Rust, L A Cohen
Jan 1, 1994·Anaesthesia·L Claybon
Jan 1, 1993·Anesthesiology·R McKenzieA Joslyn
Mar 1, 1993·Anaesthesia·J P DupeyronL A Kaplan
Apr 1, 1996·British Journal of Anaesthesia·A J WilsonK L Kong
Sep 1, 1997·Journal of Clinical Anesthesia·W S JellishJ P Leonetti
Citations
Apr 6, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Ashraf S Habib, Tong J Gan
May 24, 2007·Der Anaesthesist·M R Tramèr
Aug 30, 2007·Der Anaesthesist·C C ApfelF-J Kretz
Mar 24, 2000·Drugs·A L Kovac
Mar 3, 2005·CNS Drugs·Tong J Gan
Aug 29, 2003·Expert Opinion on Pharmacotherapy·Marianne Tan
Apr 2, 2003·Expert Opinion on Pharmacotherapy·Ashraf S Habib, Tong J Gan
Jun 19, 2015·BMC Medicine·Andrea C TriccoSharon E Straus
Sep 1, 2007·Current Therapeutic Research, Clinical and Experimental·Azize BestasErhan Aygen
Jul 20, 2014·Journal of Anesthesia·Tae Soo HahmJun Heum Yon
May 4, 2006·The Annals of Pharmacotherapy·Anthony L Kovac
Jun 24, 2003·Anesthesia and Analgesia·Tong J GanUNKNOWN Department of Anesthesiology, Duke University Medical Center
Mar 15, 2006·AORN Journal·Thomas Board, Rhonda Board
Jan 24, 2007·Anesthesia and Analgesia·Sahar M Siddik-SayyidAnis S Baraka
May 22, 2007·Anesthesia and Analgesia·Keith A CandiottiDavid A Lubarsky
Oct 11, 2005·European Journal of Anaesthesiology·R D'AngeloA Coop
Mar 1, 2003·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Anthony L Kovac
Mar 18, 2008·Arquivos brasileiros de endocrinologia e metabologia·Eduardo Cantoni RosaOsvaldo Kohlmann
May 17, 2019·Anesthesia and Analgesia·Tong J Gan, Charles M Mouch
Mar 12, 2010·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Tom Heier
Nov 25, 2004·The Oncologist·Matti Aapro
Apr 5, 2020·Expert Review of Clinical Pharmacology·Gabriel Fox, Peter Kranke
Jun 26, 2001·Acta Anaesthesiologica Scandinavica·P KrankeN Roewer
Dec 6, 2001·BMC Anesthesiology·Faranak Kazemi-KjellbergMartin R Tramèr
Jun 11, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Julie GolembiewskiTania Chopra
Oct 20, 2020·The Cochrane Database of Systematic Reviews·Stephanie WeibelPeter Kranke
Feb 24, 2001·Gastroenterology·E M QuigleyH P Parkman
May 22, 2010·Anesthesiology Clinics·Tina P Le, Tong Joo Gan