A double-blind, parallel-group, placebo-controlled, dose-ranging, multicenter study of intravenous granisetron in the treatment of postoperative nausea and vomiting in patients undergoing surgery with general anesthesia

Journal of Clinical Anesthesia
A M TaylorP L Houweling

Abstract

To compare the effectiveness of granisetron with placebo in the treatment of established postoperative nausea and vomiting (PONV). Randomized, placebo-controlled study. 34 hospitals in Europe, Scandinavia, and South Africa. 519 ASA physical status I, II, and III patients who developed PONV within 4 hours of the end of surgery performed with general anesthesia. Patients received a single intravenous dose of granisetron 0.1 mg, 1 mg, or 3 mg, or placebo when symptoms of nausea or vomiting were experienced. Additional rescue medication could be given at the investigator's discretion if nausea and vomiting were not controlled. At all doses investigated, granisetron was significantly more effective (p < or = 0.001) than placebo in controlling vomiting: 38%, 46%, and 49% of patients receiving granisetron, 0.1 mg, 1.0 mg, and 3.0 mg, respectively, experienced no vomiting in the first 24 hours following drug administration, compared with 20% receiving placebo. There was a statistically significant linear relationship between vomiting control and granisetron dose (p < 0.001). Survival distributions of time to resolution of vomiting confirmed the statistically significant difference between patients receiving granisetron and those receiv...Continue Reading

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Citations

Apr 6, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Ashraf S Habib, Tong J Gan
May 24, 2007·Der Anaesthesist·M R Tramèr
Apr 2, 2003·Expert Opinion on Pharmacotherapy·Ashraf S Habib, Tong J Gan
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Mar 12, 2010·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Tom Heier
Apr 5, 2020·Expert Review of Clinical Pharmacology·Gabriel Fox, Peter Kranke
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Feb 24, 2001·Gastroenterology·E M QuigleyH P Parkman

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