Nov 9, 2018

A Double-Blind Pilot Dosing Study of Low Field Magnetic Stimulation (LFMS) for Treatment-Resistant Depression (TRD)

BioRxiv : the Preprint Server for Biology
Marc J DubinFaith M Gunning


Low Field Magnetic Stimulation is a potentially rapid-acting treatment for depression with mood-enhancing effects in as little as one 20-minute session. The most convincing data for LFMS has come from treating bipolar depression. We examined whether LFMS also has rapid mood-enhancing effects in treatment-resistant major depressive disorder, and whether these effects are dose-dependent. We hypothesized that a single 20-min session of LFMS would reduce depressive symptom severity and that the magnitude of this change would be greater after three 20-min sessions than after a single 20-min session. In a double-blind randomized controlled trial, 30 participants (age 21-65) with treatment-resistant depression were randomized to three 20-minute active or sham LFMS treatments with 48 hours between treatments. Response was assessed immediately following LFMS treatment using the 6-item Hamilton Depression Rating Scale (HAMD-6), the Positive and Negative Affect Scale (PANAS) and the Visual Analog Scale. Following the third session of LFMS, the effect of LFMS on VAS and HAMD-6 was superior to sham (F(1; 24) = 7:45, p = 0:03, Holm-Bonferroni corrected; F(1; 22) = 6:92, p = 0:03, Holm-Bonferroni corrected, respectively). There were no differ...Continue Reading

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Mentioned in this Paper

Biological Markers
Salicylhydroxamic acid
Visual Analog Pain Scale
Hamilton Rating Scale for Depression
AS 6
Randomized Controlled Trial (Publication)
Iron Deficiency
Controlled Clinical Trials, Randomized

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