PMID: 16614542Apr 15, 2006Paper

A double-blind, placebo-controlled, crossover trial of topiramate in essential tremor

Clinical Neuropharmacology
Nafsika Frima, Richard A Grünewald

Abstract

The antiepileptic drug topiramate has been reported to improve essential tremor, but clinical trials have been small and of unsatisfactory design. We undertook a double-blind, placebo-controlled crossover study of topiramate in essential tremor, using accelerometry, spirography, and an activities of daily living questionnaire. Sixteen subjects were recruited between January and June 2002. Three withdrew consent, 13 commenced the study, and 10 finished it. Subjects were assessed at baseline and after 2, 4, and 6 weeks of treatment (placebo or topiramate doses 25, 50, and 100 mg daily). Following a washout period of 1 week, patients crossed over to the alternate arm of the study. Statistical analysis followed the method described by Altman. There was no period effect or treatment-period interaction. No outcome measure improved significantly in the active treatment period as compared with the placebo control period, although 4 of the 10 patients improved in at least 2 of the 3 outcome measures during the active treatment phase, and none during the control treatment phase. This study provided no evidence of therapeutic benefit of topiramate in essential tremor. A marginally larger study would be required formally to exclude a usefu...Continue Reading

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Citations

Aug 19, 2011·Annals of Indian Academy of Neurology·Pramod Kumar Pal
Oct 22, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Susanne A Schneider, Günther Deuschl
Nov 30, 2014·Neurologic Clinics·Susanne A Schneider, Günther Deuschl
Apr 7, 2010·Expert Opinion on Drug Safety·Jurjen J Luykx, Johannes A Carpay
Jan 25, 2011·Lancet Neurology·Günther DeuschlRodger Elble
May 17, 2008·CNS Neuroscience & Therapeutics·Richard P Shank, Bruce E Maryanoff
Oct 27, 2015·The Cerebellum·Juan Marin-Lahoz, Alexandre Gironell
Apr 15, 2017·The Cochrane Database of Systematic Reviews·Elisa BrunoMario Zappia
Sep 15, 2017·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F Hopfner, G Deuschl
May 3, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Joaquim J FerreiraUNKNOWN MDS Task Force on Tremor and the MDS Evidence Based Medicine Committee
Oct 3, 2019·Postgraduate Medical Journal·Soumya Sharma, Sanjay Pandey
Jan 25, 2020·Current Neuropharmacology·Hortensia Alonso-NavarroFélix J Jiménez-Jiménez
Sep 12, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Franziska Hopfner, Günther Deuschl

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