A double-blind placebo-controlled pilot study of glutamine therapy for abnormal intestinal permeability in patients with AIDS

The American Journal of Gastroenterology
C M NoyerV Nehra

Abstract

Up to 20% of patients with AIDS have abnormal intestinal permeability (IP). Glutamine seems to play an important role in preventing the increase in IP and loss of intestinal mucosal mass associated with total parenteral nutrition, and may be superior to glucose for oral rehydration in the setting of intestinal infection. This study was designed to see if supplemental glutamine could alter the abnormal IP of AIDS. Randomly chosen patients with AIDS from the Jacobi Medical Center human immunodeficiency virus (HIV) clinic underwent IP testing using lactulose and mannitol. Those with abnormal IP were enrolled. Duodenal biopsies were performed with a Crosby capsule and the patients were randomized in a double-blind fashion to receive placebo or glutamine (4 g/day or 8 g/day) for 28 days, after which intestinal permeability tests and duodenal biopsies were repeated. Intestinal morphology was graded by ratio of villus height to crypt depth, and by degree of inflammation. All patients complied with the therapy and there were no dropouts or reported side effects. The results showed less worsening of IP with the 4 g/day dose, compared with placebo. At the 8 g/day dose, there was stabilization of IP and improved absorption of mannitol. In...Continue Reading

References

Jan 1, 1991·Immunologic Research·R UllrichM Zeitz
Mar 1, 1991·Annals of Internal Medicine·J K GreensonJ G Bartlett
Sep 1, 1988·Digestive Diseases and Sciences·M A AntonyL H Bernstein
Oct 1, 1985·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·E A NewsholmeM S Ardawi
Oct 1, 1984·Annals of Internal Medicine·D P KotlerP R Holt
May 1, 1995·Gastroenterology·I BjarnasonD Hollander
Feb 1, 1995·Scandinavian Journal of Gastroenterology·M WirénJ Larsson
Mar 1, 1996·The British Journal of Surgery·J C HallR McCauley
Mar 1, 1996·Medical Hypotheses·J K Shabert, D W Wilmore

❮ Previous
Next ❯

Citations

Jul 1, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Oluma Y BushenRichard L Guerrant
Jan 25, 2017·AIDS Research and Human Retroviruses·Thomas R ZieglerAllison Ross Eckard
May 14, 2005·Critical Care Medicine·Daurea A De-Souza, Lewis J Greene
Jun 2, 2016·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Manpreet S MundiRyan T Hurt
Mar 19, 2003·Current Infectious Disease Reports·Benedito A. Carneiro-FilhoRichard L. Guerrant
Sep 12, 2000·Current Gastroenterology Reports·A L Buchman
Jul 15, 2004·Oncology Nursing Forum·Muriel J Montbriand
Oct 7, 2006·Current Opinion in Gastroenterology·S SmaleI Bjarnason
Apr 27, 2002·The American Journal of Clinical Nutrition·Christopher DugganW Allan Walker
Jul 14, 2001·The American Journal of Clinical Nutrition·A L Buchman
May 13, 2017·International Journal of Molecular Sciences·Min-Hyun Kim, Hyeyoung Kim
Feb 13, 2002·Journal of Infusion Nursing : the Official Publication of the Infusion Nurses Society·Gayle Katzen Savy
Jul 26, 2000·Medicine and Science in Sports and Exercise·C J FieldV C Pratt
Jan 23, 2021·Clinical Science·Sandro Massao HirabaraRui Curi
May 23, 2006·Neurobiology of Learning and Memory·S P FernandesS R Robinson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Margo N WoodsTamsin A Knox
Journal of Acquired Immune Deficiency Syndromes : JAIDS
Donald Kotler, Christine Wanke
Journal of Pediatric Gastroenterology and Nutrition
Harland S WinterPediatric AIDS Clinical Trials Group Protocol 247 Study Team
© 2022 Meta ULC. All rights reserved