A double-blind, placebo-controlled, randomized clinical trial of oral selegiline hydrochloride for smoking cessation in nicotine-dependent cigarette smokers.

Drug and Alcohol Dependence
A H WeinbergerT P George

Abstract

The primary aim of this study was to determine the safety and efficacy of the monoamine oxidase-B (MAO-B) inhibitor selegiline hydrochloride (SEL, l-Deprenyl; Eldepryl) as an aid for smoking cessation in cigarette smokers. One hundred and one nicotine-dependent adult cigarette smokers without current psychiatric or substance use disorders participated in this 8-week randomized, double-blind, placebo-controlled trial. Participants received either SEL (5mg bid, n=51) or placebo (PLO, n=50), in combination with brief (<10 min) manualized smoking cessation counseling. The main smoking outcome measures were 7-day point prevalence abstinence at end of trial (EOT), 4-week continuous smoking abstinence at end of trial (CA), and 7-day point prevalence abstinence at 6-month follow-up (6MFU). Abstinence was determined by an absence of self-reported cigarette smoking and biochemically verified by expired breath carbon monoxide and plasma cotinine levels. Rates of smoking abstinence did not differ by medication group (EOT: SEL=16%, PLO=20%, p=0.57; CA: SEL=14%, PLO=18%, p=0.56; 6MFU: SEL=12%, PLO=16%, p=0.54). Adverse events were modest and comparable between medication groups. Participants receiving SEL were more likely than those receivin...Continue Reading

Associated Clinical Trials

Citations

Jul 21, 2010·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Andrea H WeinbergerTony P George
Aug 19, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Roberta KahnAhmed Elkashef
May 1, 2010·Therapeutic Advances in Chronic Disease·Giuseppina CasellaRiccardo Polosa
Mar 25, 2014·Expert Opinion on Emerging Drugs·Muhamad Y Elrashidi, Jon O Ebbert
Jan 25, 2011·Trends in Pharmacological Sciences·Riccardo Polosa, Neal L Benowitz
Jan 18, 2011·Addictive Behaviors·Andrea H WeinbergerSherry A McKee
Mar 16, 2013·British Journal of Clinical Pharmacology·Henri-Jean AubinIvan Berlin
Oct 29, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Ron C Hogg
Jan 13, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Jane E SarginsonGreer M Murphy
Aug 28, 2013·Expert Opinion on Pharmacotherapy·Jacques Le Houezec, Henri-Jean Aubin
Mar 9, 2012·Current Opinion in Pharmacology·Pasquale CaponnettoRiccardo Polosa
Mar 13, 2015·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Terril L VerplaetseSherry A McKee
Feb 14, 2018·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Giulia A AldiFiammetta Cosci
Jan 10, 2014·The Cochrane Database of Systematic Reviews·John R HughesTim Lancaster
Apr 23, 2020·The Cochrane Database of Systematic Reviews·Seth HowesNicola Lindson
Oct 21, 2016·Clinical Pharmacokinetics·Gail D Anderson, Lingtak-Neander Chan
Apr 12, 2011·CNS Drugs·Tobias Raupach, Constant P van Schayck
Aug 22, 2013·The Cochrane Database of Systematic Reviews·Regina M van der MeerPim Cuijpers
Dec 19, 2017·Pharmacotherapy·Nieves Gómez-CoronadoSeetal Dodd
Sep 20, 2019·Therapeutic Advances in Respiratory Disease·Tatsuya NaganoYoshihiro Nishimura

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