A double-blind, placebo-controlled randomized comparison of pre and postoperative administration of ketorolac and tramadol for dental extraction pain.

Journal of Anaesthesiology, Clinical Pharmacology
Hitesh Mishra, Farhan Ahmad Khan

Abstract

To compare the analgesic efficacy and safety of single-dose oral ketorolac and tramadol administered pre and postoperatively for dental extraction pain. 74 patients undergoing third molar extraction (impacted or other causes) were recruited into the study, over a period of 1 year. The patients were divided into six groups and they were given ketorolac (20 mg), tramadol (100 mg), or placebo either preoperatively or postoperatively (half an hour before or half an hour after the procedure). Placebo was glucose powder filled in empty capsule. Pain assessment was done using a modified Verbal Rating Scale (VRS) at 30 min, 2, 4, and 6 h after the procedure. A record of whether rescue analgesic (ibuprofen 400 mg) was taken during the 6 h study period, along with the time it was taken, was made. Record of any adverse effects experienced by the patient was also kept. Maximum pain scores for each of the six study groups, over the 6 h study period, were noted. Ketorolac and tramadol were significantly better than placebo in relieving molar tooth extraction pain. Postoperative administration of tramadol was found to be more efficacious than preoperative administration in relieving the pain, whereas the preoperative administration of ketorol...Continue Reading

Citations

Jun 17, 2014·The British Journal of Oral & Maxillofacial Surgery·Mario Alberto Isiordia-EspinozaOthoniel Hugo Aragon-Martinez
Sep 18, 2013·International Journal of Oral and Maxillofacial Surgery·J Perez-UrizarA Pozos-Guillen
Jun 7, 2015·Pain Management Nursing : Official Journal of the American Society of Pain Management Nurses·Maija RantalaPäivi Kankkunen
Dec 14, 2012·The Cochrane Database of Systematic Reviews·Blánaid DalyHelen V Worthington
Feb 16, 2021·Journal of Dental Anesthesia and Pain Medicine·Sunnypriyatham TirupathiRama Brahman Lanke
May 28, 2021·European Journal of Dentistry·Diane Isabel SelvidoNatthamet Wongsirichat
Jun 15, 2021·The Cochrane Database of Systematic Reviews·Brett DolemanJohn P Williams
Aug 28, 2021·Journal of Pharmacy & Bioallied Sciences·Lavanya ThotaVinutha V Kumari

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