PMID: 7654486Jun 1, 1995

A double-blind, placebo controlled study of the effect of the specific histamine H1-receptor antagonist, terfenadine, in chronic severe asthma

British Journal of Clinical Pharmacology
R Wood-BakerS T Holgate

Abstract

1. The characteristic changes seen in asthma are widely regarded as being caused by local mediator release in the airways, with histamine the first putative mediator in asthma to be identified. 2. We performed a double-blind, randomised, placebo-controlled crossover trial of the effect of 4 weeks treatment with terfenadine 120 mg twice daily in chronic severe asthma. 3. Forty-two subjects (20 male and 22 female) completed the 10 week study. 4. Terfenadine had no significant treatment effect on the primary efficacy variables measured. Mean (95% CI) measurements for terfenadine vs placebo treatment periods were 1.5 vs 1.5 (-0.3, 0.3) l for FEV1, 259 vs 260 (-42, 40) l min-1 for morning PEF and 0.8 vs 0.8 (-0.3, 0.3) for global symptom scores. 5. Bronchodilator use and sleep disturbance, the secondary efficacy variables studied, showed an improvement during terfenadine treatment but this only reached statistical significance for the number of times subjects awoke from sleep (P = 0.04). 6. There was a similar frequency of minor adverse effects reported during placebo (13.6%) and terfenadine (16.7%) treatments. 7. Addition of the potent and specific histamine H1-receptor antagonist terfenadine to maintenance asthma treatment had no ...Continue Reading

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Citations

Aug 1, 1990·British Journal of Clinical Pharmacology·P RaffertyS T Holgate
Sep 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J H DijkmanE H Van Ganse
Aug 1, 1990·The American Review of Respiratory Disease·R DjukanovićS T Holgate
Mar 11, 1989·Lancet·W R RocheS T Holgate
Nov 1, 1989·The Journal of Allergy and Clinical Immunology·W W Busse, C A Swenson
Feb 1, 1987·The Journal of Allergy and Clinical Immunology·K R Patel
Feb 1, 1985·The Journal of Allergy and Clinical Immunology·M J Cushley, S T Holgate
Dec 1, 1987·British Journal of Clinical Pharmacology·A TaytardP J Lewis
Apr 1, 1985·Agents and Actions·J G de MonchyK de Vries
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Related Concepts

Histamine Measurement
Sleep, Slow-Wave
Peak Expiratory Flow Rate Measurement
Antagonist Muscle Action
Cross-Over Studies
Adverse Effects
Etiology
Bronchodilator Agents
HRH1
Asthma

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