PMID: 3320184Jul 1, 1987Paper

A double-blind placebo controlled trial of a selective beta 2 adrenoceptor antagonist (ICI 118551) in chronic anxiety

International Clinical Psychopharmacology
D J KingJ K Gilbert

Abstract

ICI 118551, a selective beta 2 adrenoceptor antagonist, was compared with placebo and propranolol in a double-blind cross-over trial in 11 chronically anxious patients, 8 of whom were continued on benzodiazepines. Each treatment was given for 1 week and there was a significant improvement in anxiety ratings (p less than 0.01) at the end of the 3-week trial. However there was no significant difference between the 3 treatments and no preference by either patients or doctor for any one treatment could be detected. Thus, under the conditions of this study, no beneficial effects of either selective or non-selective beta-blockade on chronic anxiety could be detected. Some previous studies with beta-blockers may have confused an effect on anxiety with an effect on benzodiazepine withdrawal.

Citations

Apr 1, 1994·Pharmacology, Biochemistry, and Behavior·E PrzegalińskiE Tatarczyńska
Nov 1, 1990·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·S J CooperA Gilliland
Jun 1, 1990·The Australian and New Zealand Journal of Surgery·J M HutsonM Fallat
Dec 1, 1987·British Journal of Clinical Pharmacology·D JeffersonJ M Patrick

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