PMID: 8598592Mar 13, 1996Paper

A double-blind, placebo-controlled trial of desipramine for primary alcohol dependence stratified on the presence or absence of major depression

JAMA : the Journal of the American Medical Association
B J MasonR B Cutler

Abstract

To assess the use of desipramine for secondary depression in primary alcohol dependence and its effect on abstinence. Randomized, double-blind, placebo-controlled trial, with stratification on the presence of secondary depression. Seventy-one volunteer and referred patients with primary alcohol dependence, abstinent a median of 8 days before randomization. A subset of 28 patients had major depression secondary to alcoholism. The outpatient psychiatry departments of two urban medical centers. Six months of a clinically determined dose of desipramine. Hamilton Depression Rating Scale, and Time Line Follow Back Interview, with breath alcohol concentrations and collateral verification. Hamilton Depression scores of desipramine-treated depressed alcoholics decreased significantly, controlling for baseline Hamilton Depression scores (P=.04). Overall, patients were abstinent significantly longer when receiving desipramine (P=.03). Rates of relapse of depressed vs nondepressed patients, analyzed separately, were not significant, although the survival function approached significance for the depressed subgroup (P=.09). Desipramine-treated depressed patients were more satisfied and were rated as more improved. Major depression secondary ...Continue Reading

Citations

Sep 22, 2010·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Conor K Farren, Sharon McElroy
May 27, 2006·Journal of Psychiatric Practice·Aron N StarostaJoseph R Volpicelli
Jun 29, 2006·JAMA : the Journal of the American Medical Association·Mary A Whooley
Oct 16, 2002·Journal of Psychosomatic Research·Paolo Cassano, Maurizio Fava
Mar 9, 2000·Addictive Behaviors·C D Williams, L L Adams-Campbell
Mar 12, 2003·Addictive Behaviors·Carolyn E SwearingenJohn W Finney
Oct 11, 2011·Addictive Behaviors·Thomas M KellyAntoine B Douaihy
Dec 19, 2006·American Journal of Preventive Medicine·Uma Rao
Feb 20, 2004·The American Journal on Addictions·Henry R Kranzler, Richard N Rosenthal
May 29, 2004·Alcoholism, Clinical and Experimental Research·Jack R CorneliusThomas M Kelly
Oct 24, 2008·Alcoholism, Clinical and Experimental Research·Tracy L SimpsonMurray Raskind
Jan 3, 2013·Alcoholism, Clinical and Experimental Research·Lorenzo Leggio, George A Kenna
Dec 22, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·John LiappasAndreas Rabavilas
Nov 24, 2004·Biological Psychiatry·Helen M Pettinati
Dec 2, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Irene D MartijenaVíctor A Molina
Dec 11, 2003·Obstetrics and Gynecology Clinics of North America·Geetanjali Chander, Mary E McCaul
Nov 20, 2004·The Psychiatric Clinics of North America·Hugh MyrickHamilton Peters
Jan 1, 2011·International Journal of Psychiatry in Medicine·Peter M MillerScott H Stewart
Nov 12, 2005·Substance Use & Misuse·Kathleen T Brady, Marcia L Verduin
Apr 27, 2004·Journal of Psychopharmacology·J LiappasG Christodoulou
Sep 23, 2000·Journal of Geriatric Psychiatry and Neurology·D W Oslin
Feb 6, 1998·Psycho-oncology·J C Lundberg, S D Passik
Nov 19, 2003·Journal of Clinical Psychopharmacology·Darlene H MoakRamon Durazo-Arvizu
Apr 25, 2018·The Cochrane Database of Systematic Reviews·Roberta AgabioPier Paolo Pani
Nov 18, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ismene L PetrakisJohn H Krystal
Oct 6, 2004·Expert Opinion on Pharmacotherapy·Darlene H Moak
Jan 4, 2019·Expert Opinion on Pharmacotherapy·Thomas Hillemacher, Helge Frieling
Jul 11, 2006·Drugs·Benjamin I GoldsteinClaudio A Naranjo
Sep 14, 2006·Current Psychiatry Reports·Edward V Nunes, Frances R Levin
Jul 2, 2005·Journal of Psychiatric Practice·J F Goldberg
Jan 18, 2006·Journal of Clinical Psychopharmacology·Henry R KranzlerMartin Keller
Feb 2, 2006·The American Journal on Addictions·Vito Agosti, Frances R Levin
Feb 1, 2004·Acta Neuropsychiatrica·M T Abou-Saleh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.