A double-blind randomised controlled trial of the effects of medroxyprogesterone acetate on bone density of women taking oestrogen replacement therapy

British Journal of Obstetrics and Gynaecology
J D AdachiC H Goldsmith

Abstract

To assess the effects of medroxyprogesterone acetate on bone density in women who have had a hysterectomy. Randomised, double-blind, placebo-controlled trial of medroxyprogesterone acetate 10 mg, 20 mg or placebo as an adjunct to oestrogen therapy. One hundred and twenty-three women, aged 18 to 45 years and currently receiving daily oestrogen, who presented at a university-based rheumatology practice. The women were randomly assigned to receive either medroxyprogesterone acetate 10 mg, 20 mg or placebo daily beginning on day 15 of each month for one year. Forty-one women were randomised into each group. The primary outcome measurement was the percentage of change from baseline in bone mineral density of the lumbar spine (L2-L4). Secondary outcome measures included differences in femoral neck bone density, cholesterol and triglyceride levels between groups. At one year, change in bone mineral density did not differ between either the treatment or placebo groups. Medroxyprogesterone acetate 20 mg and 10 mg led to statistically significant reductions in very low density lipoprotein cholesterol, total triglycerides, and very low density lipoprotein triglycerides when compared with placebo. Medroxyprogesterone acetate 20 mg also led...Continue Reading

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Citations

Jun 2, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M H KrielC S J Probert
Dec 13, 2003·Maturitas·Jos H H Thijssen
Aug 14, 2015·Trends in Cardiovascular Medicine·Georgina E Hale, Chrisandra L Shufelt
Nov 6, 2010·Journal of Osteoporosis·Vanadin Seifert-Klauss, Jerilynn C Prior
Dec 31, 2004·Obstetrics and Gynecology·Carmine NappiMaurizio Guida
Sep 14, 2002·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·J H Thijssen, R Druckmann
Jan 12, 2001·Physiological Reviews·J E Compston

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