PMID: 16522919Mar 9, 2006Paper

A double-blind, randomized, clinical trial of the effect of vitamin A and zinc supplementation on diarrheal disease and respiratory tract infections in children in Mexico City, Mexico

The American Journal of Clinical Nutrition
Kurt Z LongJorge L Rosado

Abstract

The efficacy of micronutrient supplementation in improving childhood health and survival in developing countries may be specific to the micronutrient used and health outcome measured. We evaluated the effect of vitamin A and zinc supplementation on overall rates of childhood diarrheal disease and respiratory tract infections and rates stratified by household and personal characteristics. A double-blind, randomized, placebo-controlled trial was carried out in which 736 children aged 6-15 mo living in a periurban area of Mexico City were assigned to receive vitamin A every 2 mo, zinc daily, vitamin A and zinc together, or placebo. Children were followed for 12 mo to determine overall counts of diarrheal episodes and respiratory tract infections. Vitamin A supplementation was associated with a 27% increase in diarrheal disease [risk ratio (RR): 1.27; 95% CI: 1.10, 1.45; P < 0.001] and a 23% increase in cough with fever (RR: 1.23; 95% CI: 1.02, 1.47; P = 0.02), whereas zinc had no effect on these outcomes. Vitamin A supplementation decreased diarrhea in children from households with dirt floors but increased diarrhea in children from households with nondirt floors, piped water, and indoor bathrooms. Zinc supplementation decreased d...Continue Reading

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Citations

Jun 30, 2014·The Cochrane Database of Systematic Reviews·Anjana Gulani, Harshpal S Sachdev
Aug 17, 2014·BMC Public Health·Günther Fink, Jesse Heitner
Dec 21, 2016·The Cochrane Database of Systematic Reviews·Marzia Lazzerini, Humphrey Wanzira
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May 29, 2009·Food and Nutrition Bulletin·Kenneth H BrownSonja Y Hess
Feb 7, 2008·The Cochrane Database of Systematic Reviews·H ChenT Wu
Mar 11, 2017·The Cochrane Database of Systematic Reviews·Aamer ImdadZulfiqar A Bhutta
Dec 5, 2016·The Cochrane Database of Systematic Reviews·Zohra S LassiZulfiqar A Bhutta
Jan 21, 2020·Food and Nutrition Bulletin·Yanelli Rodríguez-CarmonaJ Salmerón
May 13, 2008·The American Journal of Clinical Nutrition·Valentin KiedaischFlorian Lang
Apr 24, 2007·The Journal of Nutrition·Andrew M PrenticeSharon E Cox
Jun 18, 2010·The Cochrane Database of Systematic Reviews·Eliza H HumphreysGeorge W Rutherford
May 16, 2014·The Cochrane Database of Systematic Reviews·Evan Mayo-WilsonZulfiqar A Bhutta
Sep 17, 2014·The American Journal of Tropical Medicine and Hygiene·Wenlong GaoHong Yan
Feb 7, 2014·The Journal of Nutrition·Kathryn A ThorntonEduardo Villamor
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Oct 24, 2020·Nutrients·Francesco PecoraSusanna Esposito
Aug 14, 2021·Nutrition·Mohammad Taghi BeigmohammadiZoya Asl Motallebnejad
Feb 23, 2010·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·P Gutiérrez CastrellónE Salazar Lindo

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