A double-blind, randomized comparison of low-dose rocuronium and atracurium in a desflurane anesthetic

Journal of Clinical Anesthesia
R V MiguelP Dyches


To compare the neuromuscular and hemodynamic effects of rocuronium and atracurium when administered during a desflurane-based anesthetic. Randomized, double-blind clinical trial. 51 adult ASA physical status I and II patients scheduled for general surgical operations. University-based NCI-designated cancer center. Patients received either 0.45 mg/kg rocuronium (n = 28) or atracurium 0.5 mg/kg (n = 23). Induction of anesthesia was accomplished by 2 microg/kg fentanyl intravenously (IV) and 1.5 mg/kg propofol IV and maintained by a nitrous oxide/oxygen desflurane anesthetic. A neuromuscular monitor was used at the adductor pollicis to monitor and record twitch response to train-of-four electrical stimulation. Baseline heart rate (HR) and blood pressure (BP) were measured and again at 2, 5, 10, and 15 minutes after muscle relaxant administration. Patients in the rocuronium group were found to have shorter times to 80%T(1)depression (109 +/- 53 vs. 135 +/- 47 sec), although those differences did not reach statistical significance (p = 0.07). Percent of the first twitch (T(1) ) was significantly lower in the patients receiving rocuronium at 60 seconds (53 +/- 24 vs. 73 +/- 27 sec; p = 0.006) and 90 seconds (25 +/- 22 vs. 47 +/- 29 s...Continue Reading

Associated Clinical Trials


Jan 1, 1992·Journal of Clinical Anesthesia·A F Ghouri, P F White
Nov 1, 1992·Journal of Clinical Anesthesia·C LeeM L Cheng
Oct 1, 1987·Anesthesiology·J E CannonR D Miller
Oct 1, 1984·Anesthesiology·R D MillerY J Sohn
Aug 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·E P McCoyR A Cooper
Oct 1, 1996·British Journal of Anaesthesia·N KumarG J McCarthy
Jul 21, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·H WulfD Sitzlack
Dec 4, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·D G WhalleyF G Estafanous

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Oct 5, 2006·Current Opinion in Anaesthesiology·Thomas W Cutter
Jun 28, 2003·Natural Product Reports·Kenneth W Bentley

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