A double-blind, randomized controlled trial to explore oral tranexamic acid as adjunct for the treatment for postpartum hemorrhage

Reproductive Health
Ayisha DiopBeverly Winikoff

Abstract

Oral tranexamic acid (TXA), if effective in reducing blood loss after delivery for women experiencing primary PPH, could be administered where parenteral administration is not feasible. This trial assessed the efficacy, safety, and acceptability of oral TXA when used as an adjunct to sublingual misoprostol to treat postpartum hemorrhage (PPH) following vaginal delivery. From October 2016 to January 2018, women presenting at four hospitals in Senegal and Vietnam for vaginal delivery were screened for enrollment in the trial. Women diagnosed with postpartum hemorrhage (defined as blood loss ≥700 ml) were randomized to receive either oral TXA (1950 mg) or placebo in addition to 800 mcg sublingual misoprostol. Postpartum blood loss was measured using a calibrated drape. Blood loss for all PPH cases was recorded for 2 h after administration of the drugs. The primary outcome measure was the proportion of women with bleeding controlled with the trial regimen without recourse to further treatment. Secondary outcomes including the rate of severe PPH, mean/median blood loss, use of additional uterotonics and/or interventions side effects, and acceptability were also recorded. Of the 258 women who received treatment for PPH, 128 received ...Continue Reading

References

Jan 1, 1981·European Journal of Clinical Pharmacology·A PilbrantJ Vessman
Jan 30, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ming-ying GaiKarin Tatsumoto
Mar 20, 2010·Anesthesia and Analgesia·Brian T BatemanLisa R Leffert
Mar 18, 2011·The Cochrane Database of Systematic Reviews·David A HenryKatharine Ker
Dec 16, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Nahla W ShadyAhmed M Abbas
Feb 21, 2018·The Cochrane Database of Systematic Reviews·Haleema ShakurHatem A Mousa

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Citations

Aug 4, 2021·International Journal of Obstetric Anesthesia·A ShanderL Sentilhes

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Methods Mentioned

BETA
hysterectomy

Software Mentioned

SPSS

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