A double-blind, randomized, multicenter, Italian study of frovatriptan versus rizatriptan for the acute treatment of migraine

The Journal of Headache and Pain
Lidia SaviL Pinessi

Abstract

The objective of this study was to assess patient satisfaction with acute treatment of migraine with frovatriptan or rizatriptan by preference questionnaire. 148 subjects with a history of migraine with or without aura (IHS 2004 criteria), with at least one migraine attack per month in the preceding 6 months, were enrolled and randomized to frovatriptan 2.5 mg or rizatriptan 10 mg treating 1-3 attacks. The study had a multicenter, randomized, double-blind, cross-over design, with treatment periods lasting <3 months. At the end of the study, patients assigned preference to one of the treatments using a questionnaire with a score from 0 to 5 (primary endpoint). Secondary endpoints were pain-free and pain relief episodes at 2 h, and recurrent and sustained pain-free episodes within 48 h. 104 of the 125 patients (83%, intention-to-treat population) expressed a preference for a triptan. The average preference score was not significantly different between frovatriptan (2.9±1.3) and rizatriptan (3.2±1.1). The rates of pain-free (33% frovatriptan vs. 39% rizatriptan) and pain relief (55 vs. 62%) episodes at 2 h were not significantly different between the two treatments. The rate of recurrent episodes was significantly (p<0.001) lower ...Continue Reading

References

Apr 18, 1998·Lancet·M D Ferrari
Nov 24, 1999·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·P J Goadsby
Dec 12, 2001·Cephalalgia : an International Journal of Headache·C Dahlöf
May 25, 2002·Headache·P BuchanC Ward
May 25, 2002·Headache·P BuchanS Freestone
Jul 3, 2002·Drugs·Keri Wellington, Greg L Plosker
Oct 18, 2002·Cephalalgia : an International Journal of Headache·M D FerrariR B Lipton
Nov 14, 2003·Journal of Managed Care Pharmacy : JMCP·James U Adelman, Jonathan Belsey
Aug 18, 2004·International Journal of Clinical Practice·E A Balbisi
Dec 13, 2005·Journal of Clinical Pharmacy and Therapeutics·N PoolsupM Khanthong
Jul 25, 2006·Expert Opinion on Pharmacotherapy·Roger Cady, Curtis Schreiber
Oct 24, 2006·The Journal of Headache and Pain·Alan M Rapoport
Nov 16, 2007·Expert Opinion on Pharmacotherapy·Färkkilä Markus, Kallela Mikko
Aug 30, 2008·Neuropsychiatric Disease and Treatment·Leslie Kelman
Jan 30, 2009·Headache·Richard J HargreavesFred D Sheftell
May 21, 2009·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Egilius L H Spierings, Charlotte Keywood
May 22, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Vincenzo TulloGennaro Bussone

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Citations

May 6, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Pietro CortelliGennaro Bussone
May 25, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·G AllaisG Bussone
May 29, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Flavia FranconiGennaro Bussone
May 29, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Maria Gabriella SaraccoMarco Aguggia
Dec 10, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Alessandro Della PuppaLuca Persano
May 25, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·V TulloG Allais
Jul 25, 2014·Expert Review of Neurotherapeutics·Gianni AllaisChiara Benedetto
Sep 21, 2011·Expert Opinion on Drug Metabolism & Toxicology·Andrea NegroPaolo Martelletti
Sep 15, 2011·The Journal of Headache and Pain·Peer Tfelt-Hansen, Timothy J Steiner
Apr 23, 2011·The Journal of Headache and Pain·Peer Carsten Tfelt-Hansen
Apr 29, 2015·The Journal of Headache and Pain·Stefan EversLorenzo Pinessi
Dec 3, 2016·Headache·Kasra MaasumiJennifer S Kriegler
Dec 18, 2013·The Journal of Headache and Pain·Carlo LisottoLidia Savi
Mar 3, 2012·Cephalalgia : an International Journal of Headache·Peer Tfelt-HansenUNKNOWN International Headache Society Clinical Trials Subcommittee
Aug 16, 2016·Cephalalgia : an International Journal of Headache·Kristian ThorlundPeter J Goadsby
Feb 17, 2018·Cephalalgia : an International Journal of Headache·Peer Tfelt-HansenThien Phu Do
Feb 27, 2019·Cephalalgia : an International Journal of Headache·Hans-Christoph DienerUNKNOWN International Headache Society Clinical Trials Standing Committee
Mar 13, 2012·Current Opinion in Supportive and Palliative Care·Gianluca Coppola, Jean Schoenen
Sep 22, 2020·Cephalalgia : an International Journal of Headache·Michele VianaCristina Tassorelli

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BETA
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