A double-blind, randomized, parallel-group, flexible-dose study to evaluate the tolerability, efficacy and effects of treatment discontinuation with escitalopram and paroxetine in patients with major depressive disorder

International Clinical Psychopharmacology
David S BaldwinIan Hindmarch

Abstract

This multinational, randomized, double-blind, flexible-dose study evaluated the short- and long-term antidepressant tolerability and efficacy of escitalopram and paroxetine. Tolerability was assessed by monitoring adverse events throughout the study, and discontinuation events during brief treatment interruption and tapered withdrawal. Discontinuation-emergent effects were evaluated in two separate double-blind periods. First, to mimic the consequences of non-compliance, patients were randomized to one of two treatment interruption periods (placebo-substitution for 3-5 days). Second, patients were randomized to a 1-2-week tapered withdrawal period randomly scheduled between weeks 28 and 31. The pre-specified primary efficacy endpoint was the mean change from baseline in total Montgomery-Asberg Depression Rating Scale (MADRS) score at week 8, using the principle of last observation carried forward. A total of 323 patients entered 8 weeks of double-blind treatment and received at least one flexible dose of escitalopram (10-20 mg/day) or paroxetine (20-40 mg/day). Patients who demonstrated evidence of a significant clinical improvement (Clinical Global Impression-Improvement of 1 or 2) at week 8 entered a 19-week, double-blind mai...Continue Reading

References

Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Mar 1, 1994·International Clinical Psychopharmacology·S A MontgomeryA G Patel
May 1, 1993·The American Journal of Psychiatry·W CoryellG L Klerman
Feb 29, 2000·Journal of Sex & Marital Therapy·C A McGahueyR Manber
May 29, 2000·The British Journal of Psychiatry : the Journal of Mental Science·D MichelsonR G Tepner
Dec 1, 2000·The American Journal of Psychiatry·J M Bostwick, V S Pankratz
May 1, 2002·International Clinical Psychopharmacology·A WadeK Bang Hedegaard
May 10, 2002·The Journal of Clinical Psychiatry·William J BurkeAnjana Bose
Aug 15, 2002·International Clinical Psychopharmacology·R JudgeJ G Jacobson
Dec 14, 2002·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Michael BauerUNKNOWN World Federation of Societies of Biological Psychiatry (WFSBF) Task Force on Treatment Guidelines for Unipolar Depressive Di
Jun 19, 2003·JAMA : the Journal of the American Medical Association·Ronald C KesslerUNKNOWN National Comorbidity Survey Replication
Jun 21, 2003·International Clinical Psychopharmacology·Ulla M LepolaElin Heldbo Reines
Oct 11, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Steven P Roose
Jan 1, 2003·International Journal of Psychiatry in Clinical Practice·Pascal AuquierBenoît Rive

❮ Previous
Next ❯

Citations

Dec 18, 2007·European Archives of Psychiatry and Clinical Neuroscience·Yves LecrubierEmmauelle Weiller
Sep 23, 2010·European Archives of Psychiatry and Clinical Neuroscience·George I Papakostas, Klaus Larsen
Jun 1, 2012·Current Psychiatry Reports·Gerald GartlehnerRichard A Hansen
May 29, 2013·Current Psychiatry Reports·Cesar Soutullo, Ana Figueroa-Quintana
Jun 12, 2008·International Clinical Psychopharmacology·Raymond W LamAlan G Wade
Sep 26, 2009·International Clinical Psychopharmacology·Stuart A MontgomeryKaren A Tourian
May 7, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Dorian DeshauerJeremy Grimshaw
Feb 23, 2013·Neuropsychiatric Disease and Treatment·Bernardo Dell'ossoA Carlo Altamura
Sep 3, 2010·CNS Drugs·Karly P Garnock-Jones, Paul L McCormack
Dec 18, 2013·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Ursula ReichenpfaderBradley N Gaynes
Feb 13, 2009·Current Medical Research and Opinion·Sidney H KennedyMichael E Thase
Dec 12, 2012·The Journal of Sexual Medicine·Anita H ClaytonCarol R Reed
Feb 3, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Siegfried KasperJean-Philippe Boulenger
Sep 22, 2015·Journal of Clinical Pharmacology·David F Lehmann, Sarabeth Wojnowicz
Jul 16, 2015·International Immunopharmacology·E-Jin ParkYang-Whan Jeon
Mar 11, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Jana StrohmaierMarcella Rietschel
Sep 13, 2007·The Annals of Pharmacotherapy·David S BaldwinEmmanuelle Weiller
Mar 6, 2013·Journal of Pharmacy Practice·Nikki R Ogle, Shawn R Akkerman
Dec 27, 2011·Journal of Clinical Psychopharmacology·Antonio E NardiMarcio Versiani
Jul 27, 2007·Biopharmaceutics & Drug Disposition·Christoffer BundgaardFrank Larsen
Jul 12, 2008·The Journal of ECT·Vasilios G MasdrakisGeorge N Papadimitriou
Dec 31, 2010·Journal of Clinical Psychopharmacology·Chien-Han Lai
Jan 27, 2006·The Cochrane Database of Systematic Reviews·D J SteinS Seedat
Sep 14, 2007·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Vasilios G MasdrakisConstantin R Soldatos
Jan 1, 2009·International Journal of Psychiatry in Clinical Practice·Feng XieKarina Hansen
Apr 4, 2014·The Cochrane Database of Systematic Reviews·Marianna PurgatoCorrado Barbui
Nov 8, 2014·The Cochrane Database of Systematic Reviews·Maria KleinstäuberMichael J Lambert
Dec 18, 2019·The Cochrane Database of Systematic Reviews·Philippa DaviesNicola Wiles
May 15, 2009·Journal of Clinical Psychopharmacology·Alessandro Serretti, Alberto Chiesa
Jun 11, 2009·Journal of Clinical Psychopharmacology·Sidney H Kennedy, Sakina Rizvi
Sep 19, 2017·The Cochrane Database of Systematic Reviews·Jimmy ChongPhillippa Poole
May 2, 2020·The Cochrane Database of Systematic Reviews·Sadia JanjuaPhillippa Poole
Apr 17, 2009·The Cochrane Database of Systematic Reviews·Andrea CiprianiCorrado Barbui

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.