A double-blind randomized study comparing imipramine with fluvoxamine in depressed inpatients

Psychopharmacology
Walter W Van Den BroekPeter Moleman

Abstract

To compare the efficacy of imipramine and fluvoxamine in inpatients from two centers suffering from a depressive disorder according to DSM IV criteria. The study included 141 patients with a depressive disorder according to DSM IV criteria. After a drug-free and placebo run-in period of 1 week, patients were randomized to imipramine or fluvoxamine; doses of both drugs were adjusted to a predefined target blood level. Efficacy was evaluated 4 weeks after attaining predefined adequate plasma level. The mean age of the study group (47 males, 94 females) was 51.8 (range 19-65) years. Of these 141 patients, 56 had episode duration longer than 1 year, 48 had mood congruent psychotic features, and 138 patients received medication. Seven patients did not complete the medication trial. The total number of patients using concurrent medication was 12/138 (8.6%). On the primary outcome criteria patients on imipramine improved significantly better on the change of illness severity score of the CGI (chi2 exact trend test=4.089, df=1, P=-0.048). There was no significant difference in 50% or more reduction on the HRSD, the other primary outcome criterion. On the secondary outcome criteria the mean reduction of the HRSD scores was significantly...Continue Reading

Citations

Mar 18, 2008·Journal of Clinical Psychopharmacology·Tom K BirkenhagerJan A Bruijn
Jun 13, 2009·Nordic Journal of Psychiatry·Christina M DordingDavid Mischoulon
Apr 7, 2007·Journal of Clinical Psychopharmacology·Walter W van den BroekPeter Moleman
Nov 26, 2008·Journal of Psychopharmacology·W T C J HeijnenT K Birkenhäger
May 9, 2009·Journal of Psychopharmacology·M VermeidenT K Birkenhäger
Jun 20, 2008·Journal of Psychopharmacology·W W van den BroekJ A Bruijn
Aug 1, 2015·The Cochrane Database of Systematic Reviews·Jaap WijkstraWillem A Nolen
Jul 29, 2008·Harvard Review of Psychiatry·Hesham M Hamoda, David N Osser
Oct 3, 2006·The British Journal of Psychiatry : the Journal of Mental Science·J J Vattakatuchery
May 2, 2006·The British Journal of Psychiatry : the Journal of Mental Science·Jaap WijkstraWillem A Nolen
Mar 20, 2010·The Cochrane Database of Systematic Reviews·Ichiro M OmoriToshi A Furukawa

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