PMID: 7035480Feb 1, 1982Paper

A double-blind randomized trial of low-dose oral urea to prevent sickle cell crises

Journal of Chronic Diseases
M GailH Morrow

Abstract

Seventy-nine homozygous SS patients were randomly assigned to control or oral prophylactic urea treatment in a double-blind trial designed to determine whether prophylactic oral urea, in low doses, prevents sickle cell crises. The average follow-up time for these patients was 13.7 months and 33 patients were diagnosed as having one or more crises during the study. No statistically significant treatment differences were found in weight changes, bilirubin changes, or hemoglobin changes over the course of the study or in the distribution of time to first crises or time to second crisis. This study gives no evidence in favor of the hypothesis that prophylactic oral urea, in low doses, prolongs time to crisis.

References

Jan 1, 1976·American Journal of Hematology·G J Brewer
Feb 1, 1974·Journal of Chronic Diseases·S L George, M M Desu
Sep 1, 1973·CRC Critical Reviews in Biochemistry·M Murayama
Oct 18, 1973·The New England Journal of Medicine·M HarrisM R Wills
May 1, 1972·Annals of Internal Medicine·E C LippA V Pisciotta
Jun 1, 1971·The American Journal of the Medical Sciences·R M NalbandianR L Henry
Dec 1, 1958·Journal of Chronic Diseases·S J CUTLER, F EDERER

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Citations

Oct 20, 2018·The Cochrane Database of Systematic Reviews·Srikanth Nagalla, Samir K Ballas
Mar 5, 2016·The Cochrane Database of Systematic Reviews·Srikanth Nagalla, Samir K Ballas

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