A double-blind study of SB-220453 (Tonerbasat) in the glyceryltrinitrate (GTN) model of migraine

Cephalalgia : an International Journal of Headache
J F TvedskovJ Olesen

Abstract

The need for experimental migraine models increases as therapeutic options widen. In the present study, we investigated SB-220453 for efficacy in the glyceryltrinitrate (GTN) human experimental migraine model. SB-220453 is a novel benzopyran compound, which in animal models inhibits neurogenic inflammation, blocks propagation of spreading depression and inhibits trigeminal nerve ganglion stimulation-induced carotid vasodilatation. We included 15 patients with migraine without aura in a randomized double-blind crossover study. SB-220453 40 mg or placebo was followed by a 20-min GTN infusion. Headache, scored 0-10, was registered for 12 h, and fulfillment of International Headache Society (IHS) criteria was recorded until 24 h. Four subjects had a hypotensive episode after SB-220453 plus GTN but none after GTN alone. The reaction was unexpected, since animal models and previous human studies had shown no vascular or sympaticolytic activity with SB-220453. The study was terminated prematurely due to this interaction. GTN was consistent in producing headache and migraine that resembled the patients' usual spontaneous migraine. Nine patients had GTN on both study days. Peak headache score showed a trend towards reduction after SB-22...Continue Reading

References

Jan 1, 1995·Cephalalgia : an International Journal of Headache·H K Iversen
Oct 1, 1996·Cephalalgia : an International Journal of Headache·H K Iversen, J Olesen
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Citations

Sep 4, 2009·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·A Rapoport
Jun 25, 2009·Internal and Emergency Medicine·Ivano FarinelliPaolo Martelletti
Aug 27, 2009·Internal and Emergency Medicine·Luigi Alberto Pini
Nov 6, 2007·Nature Clinical Practice. Neurology·Peter J Goadsby
Aug 27, 2005·Nature Reviews. Drug Discovery·Peter J Goadsby
Jun 17, 2006·Cephalalgia : an International Journal of Headache·G G SchoonmanR W Baumgartner
Aug 30, 2008·Cephalalgia : an International Journal of Headache·L Edvinsson, P Tfelt-Hansen
Jan 16, 2009·Cephalalgia : an International Journal of Headache·H W SchytzM Ashina
Sep 3, 2009·Cephalalgia : an International Journal of Headache·S D Silberstein
Apr 3, 2014·Iranian Red Crescent Medical Journal·Yu-Feng ShaoYi-Ping Hou
Mar 2, 2010·Expert Review of Neurotherapeutics·Michael Bjørn Russell
May 7, 2008·Expert Review of Neurotherapeutics·Justin M SmithChristopher L-H Huang
Aug 31, 2006·Expert Opinion on Emerging Drugs·Peter J Goadsby
Oct 21, 2010·Cephalalgia : an International Journal of Headache·J F TvedskovJ Olesen
May 3, 2015·Cephalalgia : an International Journal of Headache·Emma Katrine HansenJes Olesen
Oct 2, 2009·The Journal of Headache and Pain·Lars Jacob StovnerKnut Hagen
Apr 11, 2008·The Journal of Headache and Pain·H K IversenP Tfelt-Hansen
Mar 29, 2020·Cephalalgia : an International Journal of Headache·Katrine FalkenbergJes Olesen

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