PMID: 19920515Oct 1, 1993Paper

A double-masked, placebo-controlled evaluation of timolol in a gel vehicle

Journal of Glaucoma
J LaurenceT J Zimmerman

Abstract

We evaluated a topical formulation of timolol in an anionic heteropolysaccharide gellan gum (Gelrite). Fifty-five white patients with ocular hypertension entered a double-masked, placebo-controlled, four-period, incomplete block crossover study. After washout of any ocular hypotensive medications, the intraocular pressure of both eyes of all patients was measured at 0 (09:00 h), 2, 4, 6, 8, 12, and 24 h (diurnal baseline). Patients were then randomized to receive, at 2-week intervals, one drop of each of four of the six treatments in one eye (0.008% timolol gel, 0.1% timolol gel, placebo gel, 0.008% timolol solution, 0.1% timolol solution, and placebo solution). Fellow eyes received the appropriate placebo. As measured by least-squares means, adjusted for the unmedicated baseline diurnal values, there was a clear dose-response, with the 0.1% treatments being more effective ocular hypotensive agents than the 0.008% treatments, which in turn were more effective than the placebo treatments. Within each concentration at several observation points, the gel formulation elicited a 1-2-mm Hg greater efficacy than the solution. Gel-treated subjects had a greater incidence of blurred vision. We conclude that formulation of timolol with a...Continue Reading

Citations

Dec 30, 1999·Progress in Retinal and Eye Research·M F Sugrue
Sep 15, 2004·American Journal of Ophthalmology·John H K LiuRobert N Weinreb
Feb 20, 2009·Clinical Pharmacology and Therapeutics·G D Novack
Jun 29, 1999·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·W C StewartJ A Stewart
Aug 25, 2020·Expert Opinion on Pharmacotherapy·Aakriti G ShuklaJonathan S Myers

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