Jun 2, 2020

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo

Journal of Visualized Experiments : JoVE
Yihai LiuWei Huang

Abstract

Dilated cardiomyopathy (DCM) refers to a spectrum of heterogeneous myocardial disorders characterized by ventricular dilation and depressed cardiac performance in the absence of hypertension, valvular, congenital, or ischemic heart diseases, and which may be related to infection, autoimmune or metabolic abnormalities, or family inheritance. It can progress into congestive heart failure with a poor prognosis. Doxorubicin (Dox) is widely employed as a chemotherapeutic drug, but its use is limited because it causes DCM-like changes of the myocardium. Its myocardial toxicity is attributed to oxidative stress, chronic inflammation, and cardiomyocyte apoptosis. A model of DCM exploiting these Dox-induced DCM symptoms has not been established.

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Mentioned in this Paper

In Vivo
Hypertensive Disease
Congestive Heart Failure
Apoptosis
Doxorubicin
Autoimmune Diseases
Myocardium
Antineoplastic Agents
Ventricular Dilatation (Disorder)
Prognosis Bad

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