A DPP-4 inhibitor suppresses fibrosis and inflammation on experimental autoimmune myocarditis in mice

PloS One
Hiroyuki HirakawaMitsuaki Isobe

Abstract

Myocarditis is a critical inflammatory disorder which causes life-threatening conditions. No specific or effective treatment has been established. DPP-4 inhibitors have salutary effects not only on type 2 diabetes but also on certain cardiovascular diseases. However, the role of a DPP-4 inhibitor on myocarditis has not been investigated. To clarify the effects of a DPP-4 inhibitor on myocarditis, we used an experimental autoimmune myocarditis (EAM) model in Balb/c mice. EAM mice were assigned to the following groups: EAM mice group treated with a DPP-4 inhibitor (linagliptin) (n = 19) and those untreated (n = 22). Pathological analysis revealed that the myocardial fibrosis area ratio in the treated group was significantly lower than in the untreated group. RT-PCR analysis demonstrated that the levels of mRNA expression of IL-2, TNF-α, IL-1β and IL-6 were significantly lower in the treated group than in the untreated group. Lymphocyte proliferation assay showed that treatment with the DPP-4 inhibitor had no effect on antigen-induced spleen cell proliferation. Administration of the DPP-4 inhibitor remarkably suppressed cardiac fibrosis and reduced inflammatory cytokine gene expression in EAM mice. Thus, the agents present in DPP-...Continue Reading

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Citations

Feb 16, 2016·Fibrogenesis & Tissue Repair·Sen ShiKeizo Kanasaki
Jan 17, 2016·Journal of Molecular and Cellular Cardiology·Evangelos P DaskalopoulosSandrine Horman
Apr 26, 2018·Journal of Cellular Biochemistry·Suncica BuljevicJadranka Varljen
Jun 17, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rafael I JaénPatricia Prieto
May 29, 2018·Medicinal Research Reviews·Katarina TomovicAndrija Smelcerovic
Nov 8, 2016·Current Opinion in Nephrology and Hypertension·Yuta TakagakiKeizo Kanasaki
May 24, 2018·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jian XuHui Kong
Jun 22, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Aiqun PanGuoliang Xu
Jul 30, 2019·International Immunopharmacology·Yunjuan Zhao
Aug 12, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Shreyasi Gupta, Utpal Sen
Mar 19, 2019·Journal of Molecular and Cellular Cardiology·Yuri NakajimaMasafumi Kitakaze
Jul 6, 2021·JACC. Basic to Translational Science·Eliot G Peyster, Kenneth B Margulies
Jul 6, 2021·JACC. Basic to Translational Science·Yuka Shiheido-WatanabeTetsuo Sasano

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