A Drosophila model for developmental nicotine exposure

PloS One
Norma Andrea Velazquez-Ulloa

Abstract

Despite the known health risks of tobacco smoking, many people including pregnant women continue smoking. The effects of developmental nicotine exposure are known, but the underlying mechanisms are not well understood. Drosophila melanogaster is a model organism that can be used for uncovering genetic and molecular mechanisms for drugs of abuse. Here I show that Drosophila can be a model to elucidate the mechanisms for nicotine's effects on a developing organism. Drosophila reared on nicotine food display developmental and behavioral effects similar to those in mammals including decreased survival and weight, increased developmental time, and decreased sensitivity to acute nicotine and ethanol. The Drosophila nicotinic acetylcholine receptor subunit alpha 7 (Dα7) mediates some of these effects. A novel role for Dα7 on ethanol sedation in Drosophila is also shown. Future research taking advantage of the genetic and molecular tools for Drosophila will allow additional discovery of the mechanisms behind the effects of nicotine during development.

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Citations

Mar 10, 2018·Nature Communications·Vaibhav P PaiMichael Levin
May 26, 2018·Metabolic Brain Disease·Wasiu Gbolahan BalogunAzman Seeni
Jun 15, 2018·BMC Developmental Biology·Melanie MorrisNorma Andrea Velazquez-Ulloa
Jun 13, 2020·Frontiers in Cellular Neuroscience·Vaibhav P PaiMichael Levin
May 4, 2018·Frontiers in Physiology·Eve G Lowenstein, Norma A Velazquez-Ulloa
Feb 6, 2020·Scientific Reports·Christopher Amourda, Timothy E Saunders
Jan 2, 2021·Frontiers in Behavioral Neuroscience·Maggie M ChvilicekAdrian Rothenfluh
Feb 26, 2021·Scientific Reports·Natalia El-MerhieSusanne Krauss-Etschmann
Feb 11, 2021·Brain, Behavior and Evolution·Nabil Karnib, Moira J van Staaden
Dec 9, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Erasmia RoukaSotirios G Zarogiannis

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Methods Mentioned

BETA
sedation
Assay
PCR
transgenic

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